RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …

Fluorescent indicator displacement (FID) assays are an advantageous approach to convert
receptors into optical sensors that can detect binding of various ligands. In particular, the …

Metastasis-associated lung adenocarcinoma transcript 1 (Malat1/MALAT1, mouse/human),
a highly conserved long noncoding (lnc) RNA, has been linked with several physiological …

The implication of RNA in multiple cellular processes beyond protein coding has revitalized
interest in the development of small molecules for therapeutically targeting RNA and for …

In recent years, there has been dramatic growth in the study of RNA. RNA has gone from
being known as an intermediate in the central dogma of molecular biology to a molecule …

Microscale Thermophoresis (MST) is a powerful biophysical technique that measures the
mobility of biomolecules in response to a temperature gradient, making it useful for …

New drug discovery strategies are emerging at a rapid pace to combat the threat of mortality
caused by various chronic diseases viz., HIV-AIDS, respiratory infections and cancers. The …

With the rise of novel biology and high potential target identification technologies originating
from advances in genomics, medicinal chemists are progressively facing targets of …

Human Immunodeficiency Virus (HIV) type 1 uses a− 1 programmed ribosomal frameshift (−
1 PRF) event to translate its enzymes from the same transcript used to encode the virus' …

Our awareness and appreciation of the many regulatory roles of RNA have dramatically
increased in the past decade. This understanding, in addition to the impact of RNA in many …