Molecular biomarkers for vascular cognitive impairment and dementia

S Hosoki, GK Hansra, T Jayasena, A Poljak… - Nature Reviews …, 2023 - nature.com
As disease-specific interventions for dementia are being developed, the ability to identify the
underlying pathology and dementia subtypes is increasingly important. Vascular cognitive …

The pathobiology of vascular dementia

C Iadecola - Neuron, 2013 - cell.com
Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

K Deckers, MPJ van Boxtel… - … journal of geriatric …, 2015 - Wiley Online Library
Objective Dementia has a multifactorial etiology, but the importance of individual health and
lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper …

Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis

C Custodero, A Ciavarella, F Panza, D Gnocchi… - Geroscience, 2022 - Springer
Vascular contribution to cognitive impairment and dementia (VCID) is a clinical label
encompassing a wide range of cognitive disorders progressing from mild to major vascular …

Inflammatory markers and the risk of dementia and Alzheimer's disease: a meta-analysis

SKL Darweesh, FJ Wolters, MA Ikram, F de Wolf… - Alzheimer's & …, 2018 - Elsevier
Introduction Inflammatory markers are often elevated in patients with dementia, including
Alzheimer's disease (AD). However, it remains unclear whether inflammatory markers are …

A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development

RP Juster, G Bizik, M Picard… - Development and …, 2011 - cambridge.org
The allostatic load (AL) model represents an interdisciplinary approach to comprehensively
conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle …

[HTML][HTML] Vascular cognitive impairment: disease mechanisms and therapeutic implications

DA Levine, KM Langa - Neurotherapeutics, 2011 - Elsevier
The prevalence of vascular cognitive impairment (VCI) is likely to increase as the population
ages and cardiovascular disease survival improves. We provide an overview of the …

Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

J Gallacher, P Elwood, J Pickering, A Bayer… - J Epidemiol …, 2012 - jech.bmj.com
Background Benzodiazepine use is widespread in older people, although its benefit is
uncertain. Aim To investigate the long-term effect of benzodiazepine use upon dementia …

Vascular disease and dementias: paradigm shifts to drive research in new directions

MA Kling, JQ Trojanowski, DA Wolk, VMY Lee… - Alzheimer's & …, 2013 - Elsevier
Vascular disease was once considered the principal cause of aging-related dementia. More
recently, however, research emphasis has shifted to studies of progressive …

Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini‐review

BM Bettcher, JH Kramer - Clinical Pharmacology & …, 2014 - Wiley Online Library
The role of inflammation in cognitive decline has generated considerable interest, although
few longitudinal evaluations have been conducted. A review of the literature yields mixed …