Peptidomics: A review of clinical applications and methodologies
RE Foreman, AL George, F Reimann… - Journal of Proteome …, 2021 - ACS Publications
Improvements in both liquid chromatography (LC) and mass spectrometry (MS)
instrumentation have greatly enhanced proteomic and small molecule metabolomic analysis …
instrumentation have greatly enhanced proteomic and small molecule metabolomic analysis …
A simple, time-and cost-effective, high-throughput depletion strategy for deep plasma proteomics
A Viode, P van Zalm, KK Smolen, B Fatou… - Science …, 2023 - science.org
We introduce a cost-effective, robust high-throughput–compatible plasma depletion method
enabling in-depth profiling of plasma that detects> 1300 proteins per run with a throughput …
enabling in-depth profiling of plasma that detects> 1300 proteins per run with a throughput …
[HTML][HTML] Applying proteomics and integrative “Omics” strategies to decipher the chronic kidney disease-related atherosclerosis
J Tracz, M Luczak - International Journal of Molecular Sciences, 2021 - mdpi.com
Patients with chronic kidney disease (CKD) are at increased risk of atherosclerosis and
premature mortality, mainly due to cardiovascular events. However, well-known risk factors …
premature mortality, mainly due to cardiovascular events. However, well-known risk factors …
Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
T Sieckmann, G Schley, N Ögel, S Kelterborn… - Kidney International, 2023 - Elsevier
The polyamines spermidine and spermine and their common precursor molecule putrescine
are involved in tissue injury and repair. Here, we test the hypothesis that impaired polyamine …
are involved in tissue injury and repair. Here, we test the hypothesis that impaired polyamine …
Sequential precipitation and delipidation enables efficient enrichment of low-molecular weight proteins and peptides from human plasma
N Li, Y Zhou, J Wang, L Niu, Q Zhang… - Journal of proteome …, 2020 - ACS Publications
Low-molecular weight proteins and peptides (LMWPs,< 30 kDa) in human plasma serve as
potential biomarkers or drug targets and are endowed with desirable traits for biological and …
potential biomarkers or drug targets and are endowed with desirable traits for biological and …
[HTML][HTML] MS-based proteomics of body fluids: the end of the beginning
JM Bader, V Albrecht, M Mann - Molecular & Cellular Proteomics, 2023 - ASBMB
Accurate biomarkers are a crucial and necessary precondition for precision medicine, yet
existing ones are often unspecific and new ones have been very slow to enter the clinic …
existing ones are often unspecific and new ones have been very slow to enter the clinic …
[HTML][HTML] On-line coupling of two-phase microelectroextraction to capillary electrophoresis–mass spectrometry for metabolomics analyses
A Oedit, T Hankemeier, PW Lindenburg - Microchemical Journal, 2021 - Elsevier
We have integrated two-phase electroextraction (EE), capillary electrophoresis (CE) and
mass spectrometry (MS) to combine rapid sample extraction, high performance separation …
mass spectrometry (MS) to combine rapid sample extraction, high performance separation …
[HTML][HTML] Alterations of the peptidomic composition of peripheral plasma after portal hypertension correction by transjugular intrahepatic portosystemic shunt
GI Bagarolo, S Bhargava, R Schierwagen, W Gu… - npj Gut and …, 2024 - nature.com
Portal hypertension develops in patients with advanced chronic liver diseases (CLD),
especially cirrhosis and is associated with complications, such as gastrointestinal bleeding …
especially cirrhosis and is associated with complications, such as gastrointestinal bleeding …
Prediction modelling with many correlated and zero-inflated predictors: assessing a nonnegative garrote approach
M Gregorich, M Kammer, H Mischak… - arXiv preprint arXiv …, 2024 - arxiv.org
Building prediction models from mass-spectrometry data is challenging due to the
abundance of correlated features with varying degrees of zero-inflation, leading to a …
abundance of correlated features with varying degrees of zero-inflation, leading to a …
Proteomic analysis identifies dysregulated proteins in albuminuria: a South African pilot study
Albuminuria may precede decreases in glomerular filtration rate (GFR) and both tests are
insensitive predictors of early stages of kidney disease. Our aim was to characterise the …
insensitive predictors of early stages of kidney disease. Our aim was to characterise the …