Improvements in both liquid chromatography (LC) and mass spectrometry (MS)
instrumentation have greatly enhanced proteomic and small molecule metabolomic analysis …

We introduce a cost-effective, robust high-throughput–compatible plasma depletion method
enabling in-depth profiling of plasma that detects> 1300 proteins per run with a throughput …

Patients with chronic kidney disease (CKD) are at increased risk of atherosclerosis and
premature mortality, mainly due to cardiovascular events. However, well-known risk factors …

The polyamines spermidine and spermine and their common precursor molecule putrescine
are involved in tissue injury and repair. Here, we test the hypothesis that impaired polyamine …

Low-molecular weight proteins and peptides (LMWPs,< 30 kDa) in human plasma serve as
potential biomarkers or drug targets and are endowed with desirable traits for biological and …

Accurate biomarkers are a crucial and necessary precondition for precision medicine, yet
existing ones are often unspecific and new ones have been very slow to enter the clinic …

We have integrated two-phase electroextraction (EE), capillary electrophoresis (CE) and
mass spectrometry (MS) to combine rapid sample extraction, high performance separation …

Portal hypertension develops in patients with advanced chronic liver diseases (CLD),
especially cirrhosis and is associated with complications, such as gastrointestinal bleeding …

Building prediction models from mass-spectrometry data is challenging due to the
abundance of correlated features with varying degrees of zero-inflation, leading to a …

Albuminuria may precede decreases in glomerular filtration rate (GFR) and both tests are
insensitive predictors of early stages of kidney disease. Our aim was to characterise the …