Extracellular vesicles from ovarian carcinoma cells display specific glycosignatures

J Gomes, P Gomes-Alves, SB Carvalho, C Peixoto… - Biomolecules, 2015 - mdpi.com
Cells release vesicles to the extracellular environment with characteristic nucleic acid,
protein, lipid, and glycan composition. Here we have isolated and characterized …

Human cardiac progenitor cell activation and regeneration mechanisms: exploring a novel myocardial ischemia/reperfusion in vitro model

MJ Sebastião, M Serra, R Pereira, I Palacios… - Stem cell research & …, 2019 - Springer
Background Numerous studies from different labs around the world report human cardiac
progenitor cells (hCPCs) as having a role in myocardial repair upon ischemia/reperfusion …

[HTML][HTML] Bioreactor-based 3D human myocardial ischemia/reperfusion in vitro model: a novel tool to unveil key paracrine factors upon acute myocardial infarction

MJ Sebastião, P Gomes-Alves, I Reis, B Sanchez… - Translational …, 2020 - Elsevier
During acute myocardial infarction (AMI), Ischemia/Reperfusion (I/R) injury causes
cardiomyocyte (CM) death and loss of tissue function, making AMI one of the major causes …

[HTML][HTML] Proteomic and Glyco (proteo) mic tools in the profiling of cardiac progenitors and pluripotent stem cell derived cardiomyocytes: Accelerating translation into …

MJ Sebastião, L Marcos-Silva, P Gomes-Alves… - Biotechnology …, 2021 - Elsevier
Research in stem cells paved the way to an enormous amount of knowledge, increasing
expectations on cardio regenerative therapeutic approaches in clinic. While the first …

Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization

JL Torán, JA López, P Gomes-Alves, S Aguilar… - Scientific reports, 2019 - nature.com
Adult cardiac progenitor/stem cells (CPC/CSC) are multipotent resident populations involved
in cardiac homeostasis and heart repair. Assisted by complementary RNAseq analysis, we …

Comparative proteomic analysis of nuclear and cytoplasmic compartments in human cardiac progenitor cells

G Albericio, S Aguilar, JL Torán, R Yañez, JA López… - Scientific Reports, 2022 - nature.com
Clinical trials evaluating cardiac progenitor cells (CPC) demonstrated feasibility and safety,
but no clear functional benefits. Therefore a deeper understanding of CPC biology is …

In vitro expansion of human cardiac progenitor cells: exploring'omics tools for characterization of cell-based allogeneic products

P Gomes-Alves, M Serra, C Brito, CP Ricardo… - Translational …, 2016 - Elsevier
Human cardiac stem/progenitor cells (hCPCs) have been shown to be capable to
regenerate contractile myocardium. However, because of their relative low abundance in the …

Unveiling human cardiac fibroblast membrane proteome

MJ Sebastião, R Pereira, M Serra, P Gomes‐Alves… - …, 2018 - Wiley Online Library
Cardiac fibroblasts (CFs) are one of the main cell populations in the heart and play important
roles in tissue homeostasis and myocardial fibrosis. The study of these cells has been …

Improved surfaceome coverage with a label‐free nonaffinity‐purified workflow

T Glisovic‐Aplenc, S Gill, LA Spruce, IR Smith… - …, 2017 - Wiley Online Library
The proteins of the cellular plasma membrane (PM) perform important functions relating to
homeostasis and intercellular communication. Due to its overall low cellular abundance …

[Retracted] Data Fusion Algorithm for Myocardial Proteomics and Its Research in Sports

D Song, X Hu - Computational and Mathematical Methods in …, 2022 - Wiley Online Library
Sport is a type of comprehensive activity that the human body consciously engages in to
improve physical fitness. Proteomics is a comprehensive technology dedicated to the study …