[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
Lipid phenotypes and DNA methylation: a review of the literature
Abstract Purpose of Review Epigenetic modifications via DNA methylation have previously
been linked to blood lipid levels, dyslipidemias, and atherosclerosis. The purpose of this …
been linked to blood lipid levels, dyslipidemias, and atherosclerosis. The purpose of this …
Plasminogen receptors promote lipoprotein (a) uptake by enhancing surface binding and facilitating macropinocytosis
H Siddiqui, N Deo, MT Rutledge… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: High levels of Lp (a)(lipoprotein (a)) are associated with multiple forms of
cardiovascular disease. Lp (a) consists of an apoB100-containing particle attached to the …
cardiovascular disease. Lp (a) consists of an apoB100-containing particle attached to the …
Contemporary perspectives on the genetics and clinical use of lipoprotein (a) in preventive cardiology
MM Page, GF Watts - Current Opinion in Cardiology, 2021 - journals.lww.com
Measurement of Lp (a) in the clinical setting contributes to the assessment of ASCVD risk,
and will become more important with the advent of specific Lp (a)-lowering therapies …
and will become more important with the advent of specific Lp (a)-lowering therapies …
DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
VA Cameron, GT Jones, LJ Horwood, AP Pilbrow… - Clinical …, 2023 - Springer
Background Individuals born very low birthweight (VLBW) are at increased risk of impaired
cardiovascular and respiratory function in adulthood. To identify markers to predict future risk …
cardiovascular and respiratory function in adulthood. To identify markers to predict future risk …
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
Abstract Background & Methods In this study, a novel restriction enzyme (RE) digestion-
based droplet digital polymerase chain reaction (ddPCR) assay was designed for …
based droplet digital polymerase chain reaction (ddPCR) assay was designed for …
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS …
ABSTRACT DNA methylation (DNAm) epigenome-wide association studies (EWAS) have
been performed on diverse ethnicities to discover novel biomarkers associated with various …
been performed on diverse ethnicities to discover novel biomarkers associated with various …
Data Analysis of DNA MethylationEpigenome-Wide Association Studies (EWAS): A Guide to the Principles of Best Practice
Array-based EWAS have become an increasingly popular technique to identify population
epigenetic effects, particularly in humans. With the arrival of nonhuman species arrays, such …
epigenetic effects, particularly in humans. With the arrival of nonhuman species arrays, such …
Association between lipoprotein(a), LPA genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events
MK Moore, GT Jones, S McCormick… - European journal of …, 2024 - academic.oup.com
Aims Cohort studies have demonstrated associations between calcific aortic valve disease
(CAVD) and Lp (a). As Lp (a) is almost entirely genetically determined, in this study, we aim …
(CAVD) and Lp (a). As Lp (a) is almost entirely genetically determined, in this study, we aim …
Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers
Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer
risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within …
risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within …