Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

This review provides a model for the role of oxidative stress in the etiology of age-related
macular degeneration (AMD). Epidemiological studies of diet, environmental and behavioral …

Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder characterized by
increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity …

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …

The 5′-3′ resection of DNA ends is a prerequisite for the repair of DNA double strand
breaks by homologous recombination, microhomology-mediated end joining, and single …

Organisms with renewable tissues use a network of genetic pathways and cellular
responses to prevent cancer. The main mammalian tumour-suppressor pathways evolved …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic
material of somatic cells as a function of time results in a decrease in cellular function. In …

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of
the five known family members in humans give rise to debilitating disorders that are …

Recent progress in the science of aging is driven largely by the use of model systems,
ranging from yeast and nematodes to mice. These models have revealed conservation in …