1.1. Organization of Committee and Evidence Review (UPDATED) For new or updated text,
view the 2011 Focused Update and the 2011 Update on Dabigatran. Text supporting …

Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal
sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of …

Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, increasing
in prevalence with age. AF is often associated with structural heart disease, although a …

Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Triggers propagating into atrial myocardium may initiate reentering wavelets if the
wavelength is sufficiently short. Wavelength shortening can occur even in normal atria if the …

Rationale: Although research suggests that diastolic Ca2+ levels might be increased in atrial
fibrillation (AF), this hypothesis has never been tested. Diastolic Ca2+ leak from the …

Chronic atrial fibrillation (AF) is characterized by decreased atrial contractility, shortened
action potential duration, and decreased accommodation of action potential duration to …

Atrial fibrillation (AF), the most common chronic arrhythmia, increases the risk of stroke and
is an independent predictor of mortality. Available pharmacological treatments have limited …

Background—Data from studies of angiotensin-converting enzyme inhibitors provide
evidence that the renin-angiotensin-aldosterone system plays a role as a mediator of atrial …

Objectives: The purpose of the present study was to evaluate the effect of angiotensin II type
1 receptor (AT1R) antagonist on chronic structural remodeling in atrial fibrillation (AF) …