Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Non-alcoholic fatty liver disease (NAFLD)–pathogenesis, classification, and effect on drug metabolizing enzymes and transporters

E Cobbina, F Akhlaghi - Drug metabolism reviews, 2017 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …

Physiological and pathophysiological roles of NAMPT and NAD metabolism

A Garten, S Schuster, M Penke, T Gorski… - Nature Reviews …, 2015 - nature.com
Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …

Insulin-like growth factor (IGF) system in liver diseases

A Adamek, A Kasprzak - International journal of molecular sciences, 2018 - mdpi.com
Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors
produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to …

[HTML][HTML] Radiologic evaluation of nonalcoholic fatty liver disease

SS Lee, SH Park - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a frequent cause of chronic liver diseases,
ranging from simple steatosis to nonalcoholic steatohepatitis (NASH)-related liver cirrhosis …

Prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 1 diabetes mellitus: a systematic review and meta-analysis

M De Vries, J Westerink… - The Journal of …, 2020 - academic.oup.com
Context Nonalcoholic fatty liver disease (NAFLD) prevalence is high, especially in patients
with obesity and type 2 diabetes, and is expected to rise steeply in the coming decades …

[HTML][HTML] Metabolic aspects of adult patients with nonalcoholic fatty liver disease

L Abenavoli, N Milic, L Di Renzo… - World journal of …, 2016 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and it
encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The …

[HTML][HTML] Targeting inflammation in diabetes: Newer therapeutic options

NK Agrawal, S Kant - World journal of diabetes, 2014 - ncbi.nlm.nih.gov
Inflammation has been recognised to both decrease beta cell insulin secretion and increase
insulin resistance. Circulating cytokines can affect beta cell function directly leading to …

Correlation of gut Firmicutes/Bacteroidetes ratio with fibrosis and steatosis stratified by body mass index in patients with non-alcoholic fatty liver disease

COM Jasirwan, A Muradi, I Hasan… - … of microbiota, food …, 2021 - jstage.jst.go.jp
We investigated the gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD)
and its correlation with fibrosis and steatosis stratified by body mass index, as reflected in …

[HTML][HTML] Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes

A Tuttolomondo, C Maida, A Pinto - World journal of orthopedics, 2015 - ncbi.nlm.nih.gov
Diabetic foot ulcerations have been extensively reported as vascular complications of
diabetes mellitus associated with a high degree of morbidity and mortality. Diabetic foot …