The cell biology of ferroptosis

SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Exploiting ferroptosis vulnerabilities in cancer

T Nakamura, M Conrad - Nature Cell Biology, 2024 - nature.com
Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This
process has been increasingly contemplated as a new target for cancer therapy because of …

Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer

H Yang, Q Li, X Chen, M Weng, Y Huang… - Nature …, 2024 - nature.com
Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer
(GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated …

Lipidomes define immune cell identity

KR Levental, WS Henry - Nature Cell Biology, 2024 - nature.com
Diverse, specialized immune cells defend against pathogens and cancer cells. A new study
reveals the comprehensive lipid compositions of these cells, with unique lipidomes …

[PDF][PDF] Ferroptosis: principles and significance in health and disease

F Chen, R Kang, D Tang, J Liu - Journal of Hematology & Oncology, 2024 - Springer
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …

Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro

C Shao, T Luo, S Wang, Z Li, X Yu, Y Wu, S Jiang… - Chemosphere, 2024 - Elsevier
Cadmium (Cd) is an important environmental toxicant that could cause serious damage to
various organs including severe hepatotoxicity in intoxicated animals. Selenium has been …

Visualization of Phospholipid Synthesis on Tissue Sections Using Functional Mass Spectrometry Imaging

T Iwama, K Kano, H Kawana, H Shindou… - Analytical …, 2024 - ACS Publications
Functional mass spectrometry imaging (fMSI) is a potent tool for elucidating the spatial
distribution of enzyme activities in tissues at high resolution. In this study, we applied fMSI to …

Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases

J Korbecki, M Bosiacki, M Pilarczyk… - Cancers, 2024 - mdpi.com
Simple Summary This review discusses the enzymatic processes governing the initial
stages of the synthesis of glycerophospholipids (phosphatidylcholine …

[HTML][HTML] Portulaca oleracea L. polysaccharide inhibits ovarian cancer via inducing ACSL4-dependent ferroptosis

L Xia, M Yang, Y Liu - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
The antitumor effect of Portulaca oleracea L. polysaccharide (POL) has been demonstrated,
but whether it curbs the development of ovarian cancer has not been reported. Here, we …

[HTML][HTML] Complimentary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

KH Lee, AM Stafford, M Pacheco-Vergara, K Cichewicz… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Monogenic syndromes are associated with neurodevelopmental changes that result in
cognitive impairments, neurobehavioral phenotypes including autism and attention deficit …