The cell biology of ferroptosis
SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
Exploiting ferroptosis vulnerabilities in cancer
T Nakamura, M Conrad - Nature Cell Biology, 2024 - nature.com
Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This
process has been increasingly contemplated as a new target for cancer therapy because of …
process has been increasingly contemplated as a new target for cancer therapy because of …
Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer
H Yang, Q Li, X Chen, M Weng, Y Huang… - Nature …, 2024 - nature.com
Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer
(GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated …
(GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated …
Lipidomes define immune cell identity
KR Levental, WS Henry - Nature Cell Biology, 2024 - nature.com
Diverse, specialized immune cells defend against pathogens and cancer cells. A new study
reveals the comprehensive lipid compositions of these cells, with unique lipidomes …
reveals the comprehensive lipid compositions of these cells, with unique lipidomes …
[PDF][PDF] Ferroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …
peroxidation, is governed by molecular networks involving diverse molecules and …
Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro
C Shao, T Luo, S Wang, Z Li, X Yu, Y Wu, S Jiang… - Chemosphere, 2024 - Elsevier
Cadmium (Cd) is an important environmental toxicant that could cause serious damage to
various organs including severe hepatotoxicity in intoxicated animals. Selenium has been …
various organs including severe hepatotoxicity in intoxicated animals. Selenium has been …
Visualization of Phospholipid Synthesis on Tissue Sections Using Functional Mass Spectrometry Imaging
T Iwama, K Kano, H Kawana, H Shindou… - Analytical …, 2024 - ACS Publications
Functional mass spectrometry imaging (fMSI) is a potent tool for elucidating the spatial
distribution of enzyme activities in tissues at high resolution. In this study, we applied fMSI to …
distribution of enzyme activities in tissues at high resolution. In this study, we applied fMSI to …
Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases
J Korbecki, M Bosiacki, M Pilarczyk… - Cancers, 2024 - mdpi.com
Simple Summary This review discusses the enzymatic processes governing the initial
stages of the synthesis of glycerophospholipids (phosphatidylcholine …
stages of the synthesis of glycerophospholipids (phosphatidylcholine …
[HTML][HTML] Portulaca oleracea L. polysaccharide inhibits ovarian cancer via inducing ACSL4-dependent ferroptosis
L Xia, M Yang, Y Liu - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
The antitumor effect of Portulaca oleracea L. polysaccharide (POL) has been demonstrated,
but whether it curbs the development of ovarian cancer has not been reported. Here, we …
but whether it curbs the development of ovarian cancer has not been reported. Here, we …
[HTML][HTML] Complimentary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome
KH Lee, AM Stafford, M Pacheco-Vergara, K Cichewicz… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Monogenic syndromes are associated with neurodevelopmental changes that result in
cognitive impairments, neurobehavioral phenotypes including autism and attention deficit …
cognitive impairments, neurobehavioral phenotypes including autism and attention deficit …