Surface biofunctionalization aims to create cell-instructive surfaces that control the behavior
of cells and modulate cellular interactions by incorporating cell signaling moieties at the …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Aims/hypothesis We hypothesised that human beta cells are structurally and functional
polarised with respect to the islet capillaries. We set out to test this using confocal …

Integrins are transmembrane receptors that transduce biochemical and mechanical signals
across the plasma membrane and promote cell adhesion and migration. In addition, integrin …

Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-
secreting cells. What underlies the function of the islet as a unit is the close approximation …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Abstract β-Cells depend on the islet basement membrane (BM). While some islet BM
components are produced by endothelial cells (ECs), the source of others remains …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …