Knee osteoarthritis is the most common joint disease. It causes pain and suffering for
affected patients and is the source of major economic costs for healthcare systems. Despite …

Background WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study
investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in …

Abstract Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-
specific gene expression in human chondrocytes. The aim of this study was to determine …

Objective Increased activity of histone deacetylase 2 (HDAC2) has been found in patients
with osteoarthritis (OA) and cartilage matrix degradation and has been shown to mediate the …

Articular cartilage can be easily damaged from human's daily activities, leading to
inflammation and to osteoarthritis, a situation that can diminish the patients' quality of life. For …

Current gold standard to treat soft tissue injuries caused by trauma and pathological
condition are autografts and off the shelf fillers, but they have inherent weaknesses like …

Background Although the use of cardiac patches is still controversial, cardiac patch has the
significance in the field of the tissue engineered cardiac regeneration because it overcomes …

Current surgical treatments for osteochondral injuries include chondrocyte transplantation,
osteochondral grafts, and bone marrow stimulation. Despite these approaches, repaired …

Abstract Background and Aims Despite the therapeutic promise of stem cell therapy in the
treatment of inflammatory bowel diseases [IBD], most donor cell populations have to be …

Although osteoarthritis (OA) is a chronic inflammatory degenerative disease affecting
millions of people worldwide, the current therapies are limited to palliative care and do not …