Insights into the present and future of cartilage regeneration and joint repair
H Evenbratt, L Andreasson, V Bicknell, M Brittberg… - Cell Regeneration, 2022 - Springer
Knee osteoarthritis is the most common joint disease. It causes pain and suffering for
affected patients and is the source of major economic costs for healthcare systems. Despite …
affected patients and is the source of major economic costs for healthcare systems. Despite …
Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting …
G Mao, Z Zhang, S Hu, Z Zhang, Z Chang… - Stem cell research & …, 2018 - Springer
Background WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study
investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in …
investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in …
[HTML][HTML] MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3
F Meng, Z Li, Z Zhang, Z Yang, Y Kang, X Zhao… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-
specific gene expression in human chondrocytes. The aim of this study was to determine …
specific gene expression in human chondrocytes. The aim of this study was to determine …
[HTML][HTML] MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation
G Mao, Z Zhang, Z Huang, W Chen, G Huang… - Osteoarthritis and …, 2017 - Elsevier
Objective Increased activity of histone deacetylase 2 (HDAC2) has been found in patients
with osteoarthritis (OA) and cartilage matrix degradation and has been shown to mediate the …
with osteoarthritis (OA) and cartilage matrix degradation and has been shown to mediate the …
In Vivo Cartilage Regeneration with Cell-Seeded Natural Biomaterial Scaffold Implants: 15-Year Study
K Theodoridis, ME Manthou, E Aggelidou… - … Engineering Part B …, 2022 - liebertpub.com
Articular cartilage can be easily damaged from human's daily activities, leading to
inflammation and to osteoarthritis, a situation that can diminish the patients' quality of life. For …
inflammation and to osteoarthritis, a situation that can diminish the patients' quality of life. For …
Three dimensional porous scaffolds derived from collagen, elastin and fibrin proteins orchestrate adipose tissue regeneration
P Sawadkar, N Mandakhbayar… - Journal of tissue …, 2021 - journals.sagepub.com
Current gold standard to treat soft tissue injuries caused by trauma and pathological
condition are autografts and off the shelf fillers, but they have inherent weaknesses like …
condition are autografts and off the shelf fillers, but they have inherent weaknesses like …
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration
JH Wee, KD Yoo, SB Sim, HJ Kim, HJ Kim… - Biomaterials …, 2022 - spj.science.org
Background Although the use of cardiac patches is still controversial, cardiac patch has the
significance in the field of the tissue engineered cardiac regeneration because it overcomes …
significance in the field of the tissue engineered cardiac regeneration because it overcomes …
3D printed cell-laden collagen and hybrid scaffolds for in vivo articular cartilage tissue regeneration
Current surgical treatments for osteochondral injuries include chondrocyte transplantation,
osteochondral grafts, and bone marrow stimulation. Despite these approaches, repaired …
osteochondral grafts, and bone marrow stimulation. Despite these approaches, repaired …
Immunomodulatory Effect of Urine-derived Stem Cells on Inflammatory Bowel Diseases via Downregulating Th1/Th17 Immune Responses in a PGE2-dependent …
C Zhou, X Wu, H Liu, X Liu, G Liu… - Journal of Crohn's …, 2020 - academic.oup.com
Abstract Background and Aims Despite the therapeutic promise of stem cell therapy in the
treatment of inflammatory bowel diseases [IBD], most donor cell populations have to be …
treatment of inflammatory bowel diseases [IBD], most donor cell populations have to be …
Thermo-responsive gel containing hydroxytyrosol-chitosan nanoparticles (Hyt@ tgel) counteracts the increase of osteoarthritis biomarkers in human chondrocytes
A Valentino, R Conte, I De Luca, F Di Cristo, G Peluso… - Antioxidants, 2022 - mdpi.com
Although osteoarthritis (OA) is a chronic inflammatory degenerative disease affecting
millions of people worldwide, the current therapies are limited to palliative care and do not …
millions of people worldwide, the current therapies are limited to palliative care and do not …