Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1

K Maiese - Neural regeneration research, 2021 - journals.lww.com
The global increase in lifespan noted not only in developed nations, but also in large
developing countries parallels an observed increase in a significant number of non …

[HTML][HTML] Antifungal activity and mechanism of D-limonene against foodborne opportunistic pathogen Candida tropicalis

H Yu, ZX Lin, WL Xiang, M Huang, J Tang, Y Lu… - Lwt, 2022 - Elsevier
Limonene can inhibit the common spoilage fungi in food, but few studies elucidated its
antifungal activity and mechanism against Candida tropicalis to date. Therefore, this study …

Plant antimicrobial peptides: a comprehensive review of their classification, production, mode of action, functions, applications, and challenges

F Zou, C Tan, TS Shinali, B Zhang, L Zhang, Z Han… - Food & Function, 2023 - pubs.rsc.org
The emergence of pathogens resistant to conventional antibiotics and the growing interest in
developing alternative natural antimicrobial agents have prompted a search for plant …

Cellular metabolism: A fundamental component of degeneration in the nervous system

K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders

K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …

Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

A Parthasarathy, EJ Borrego, MA Savka… - Journal of Biological …, 2021 - ASBMB
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …

The metabolic basis for nervous system dysfunction in alzheimer's disease, parkinson's disease, and huntington's disease

K Maiese - Current neurovascular research, 2023 - benthamdirect.com
Disorders of metabolism affect multiple systems throughout the body but may have the
greatest impact on both central and peripheral nervous systems. Currently available …

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …