Cyclodextrin in drug delivery: Exploring scaffolds, properties, and cutting-edge applications
Cyclodextrins (CDs) are unique cyclic compounds that can form inclusion complexes via
host–guest complexation with a wide range of molecules, thereby altering their …
host–guest complexation with a wide range of molecules, thereby altering their …
Hot-melt extrusion: from theory to application in pharmaceutical formulation—where are we now?
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …
Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects
Background Hot-melt extrusion (HME) significantly affects pharmaceutical manufacturing by
enhancing drug solubility and bioavailability. Advancements in HME technology to produce …
enhancing drug solubility and bioavailability. Advancements in HME technology to produce …
Optimization of a Twin screw melt granulation process for fixed dose combination immediate release Tablets: Differential amorphization of one drug and crystalline …
Abstract Interest in Twin Screw Melt Granulation (TSMG) processes is rapidly increasing,
along with the search for suitable excipients. This study aims to optimize the TSMG process …
along with the search for suitable excipients. This study aims to optimize the TSMG process …
A review of hot melt extrusion technology: advantages, applications, key factors and future prospects
X Li, X Hong, S Shuai, X Han, C Li, H Zhang… - Journal of Drug Delivery …, 2024 - Elsevier
After decades of development, hot melt extrusion (HME) technology has matured as a well-
established pharmaceutical methodology. Through the process of extruding both drug and …
established pharmaceutical methodology. Through the process of extruding both drug and …
[HTML][HTML] Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends
Background/Objectives: This study evaluates the efficacy of twin screw melt granulation
(TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and …
(TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and …
Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D printing techniques
Abstract Three-dimensional (3D) printing is a potential technique for developing
personalized medicines. Among its applications, mold manufacturing in industrial 3D …
personalized medicines. Among its applications, mold manufacturing in industrial 3D …
[HTML][HTML] Adapting the process conditions and performance in planetary roller melt granulation (PRMG) via the planetary spindle number
T Lang, J Bartsch - Powder Technology, 2024 - Elsevier
Continuous melt granulation with a planetary roller granulator is a new continuous method
based on the orbital motion of planetary spindles driven by a rotating central spindle in a …
based on the orbital motion of planetary spindles driven by a rotating central spindle in a …
Development of Hot Melt Extruded Co-Formulated Artesunate and Amodiaquine-Soluplus® Solid Dispersion System in Fixed-Dose Form: Amorphous State …
Introduction This study aims to develop co-amorphous Solid Dispersion (SD) system
containing antimalarials Artesunate (ARS) and Amodiaquine (AMQ) to improve its oral …
containing antimalarials Artesunate (ARS) and Amodiaquine (AMQ) to improve its oral …
A New Frontier in Hypertension Management: Formulating and Characterizing Subcutaneous Implants using Hot Melt Extrusion
K Chitnis, N Narala, S Narala, SR Munnangi… - 2023 - preprints.org
Hypertension (HTN) is the foremost contributor to cardiovascular diseases (CVD), which
remain a leading cause of death. However, adherence to the properly prescribed dosage …
remain a leading cause of death. However, adherence to the properly prescribed dosage …