Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

Lipid-based nanocarriers for ophthalmic administration: towards experimental design implementation

FM González-Fernández, A Bianchera, P Gasco… - Pharmaceutics, 2021 - mdpi.com
Nanotherapeutics based on biocompatible lipid matrices allow for enhanced solubility of
poorly soluble compounds in the treatment of ophthalmic diseases, overcoming the …

Design, Characterization and Pharmacokinetic–Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of …

PS Rawat, PR Ravi, SI Mir, MS Khan, H Kathuria… - Pharmaceutics, 2023 - mdpi.com
This study developed a dual-responsive in situ gel of nebivolol (NEB), a selective β-
adrenergic antagonist. The gel could achieve sustained concentrations in the aqueous …

Dexamethasone-loaded nanostructured lipid carriers for the treatment of dry eye disease

S Kumari, M Dandamudi, S Rani, E Behaeghel, G Behl… - Pharmaceutics, 2021 - mdpi.com
Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the
ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation …

[HTML][HTML] In situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) for nose-to-brain delivery: development, characterization and deposition …

CP Costa, LN Nodilo, R Silva, E Martins… - International Journal of …, 2023 - Elsevier
The nasal route has been investigated as a promising alternative for drug delivery to the
central nervous system, avoiding passage through the blood–brain barrier and improving …

Erythromycin-loaded polymeric micelles: In situ gel development, in vitro and ex vivo ocular investigations

B Sipos, M Budai-Szűcs, D Kókai, L Orosz… - European Journal of …, 2022 - Elsevier
Our present series of experiments was to create a value-added formulation that has the
potential to exert a powerful and long-lasting antibacterial effect for use in ophthalmology …

Development and evaluation of dexamethasone-loaded bioadhesive polymeric nanocapsules for mitigating cardiac and gastric adverse effects of free …

RA Abdel-Emam, MF Ali, AS Hassan… - Journal of …, 2024 - Springer
Purpose Despite having a wide range of therapeutic advantages, dexamethasone (DEXM)-
free formulations have some negative side effects that manifest over time. Polymeric …

Design and optimization of in situ gelling mucoadhesive eye drops containing dexamethasone

B Szalai, O Jójárt-Laczkovich, A Kovács, S Berkó… - Gels, 2022 - mdpi.com
Poor bioavailability of eye drops is a well-known issue, which can be improved by
increasing the residence time on the eye surface and the penetration of the active …

[HTML][HTML] Tumor-targeted hyaluronic acid-mPEG modified nanostructured lipid carriers for cantharidin delivery: An in vivo and in vitro study

S Sun, E Shang, A Ju, Y Li, Q Wu, Q Li, Y Yang, Y Guo… - Fitoterapia, 2021 - Elsevier
Aim Cantharidin (CTD), the major component of the anti-cancer medicine obtained from
Mylabris cichorii, exerts good inhibitory effects on several cancers, such as liver and breast …

From Preformulative Design to in Vivo Tests: A Complex Path of Requisites and Studies for Nanoparticle Ocular Application. Part 2: In Vitro, Ex Vivo, and In Vivo …

C Cimino, LB Vidal, F Conti, ES López… - Molecular …, 2024 - ACS Publications
The incidence of ocular pathologies is constantly increasing, as is the interest of the
researchers in developing new strategies to ameliorate the treatment of these conditions …