The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Mucus clearance is the primary defense mechanism that protects airways from inhaled
infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel …

The vertebrate immune system is comprised of numerous distinct and interdependent
components. Every component has its own inherent protective value, and the final …

Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all,
bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of …

A characteristic feature of the human airway epithelium is the presence of ciliated cells
bearing motile cilia, specialized cell surface projections containing axonemes composed of …

The persistence of chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF)
patients is due to biofilm-growing mucoid (alginate-producing) strains. A biofilm is a …

Lung infection is the main cause of morbidity and mortality in patients with cystic fibrosis and
is mainly dominated by Pseudomonas aeruginosa. The biofilm mode of growth makes …

Mucus is tenacious. It sticks to most particles, preventing their penetration to the epithelial
surface. Multiple low-affinity hydrophobic interactions play a major role in these adhesive …

The most common cystic fibrosis mutation, ΔF508 in nucleotide binding domain 1 (NBD1),
impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain …