Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …

Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …

MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

Inflammasome activation has been implicated in various inflammatory diseases including
post-ischaemic inflammation after stroke. Inflammasomes mediate activation of caspase-1 …

Sleep is a complex physiological process that is regulated globally, regionally, and locally
by both cellular and molecular mechanisms. It occurs to some extent in all animals, although …

Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …

Traumatic brain injury (TBI) affects an ever-growing population of all ages with long-term
consequences on health and cognition. Many of the issues that TBI patients face are thought …

Previous studies have demonstrated a close association between an altered immune
system and major depressive disorders, and inhibition of neuroinflammation may represent …