Contribution of Knoevenagel condensation products toward the development of anticancer agents: An updated review

R Tokala, D Bora, N Shankaraiah - ChemMedChem, 2022 - Wiley Online Library
Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

Indole-based tubulin inhibitors: binding modes and SARs investigations

S Tang, Z Zhou, Z Jiang, W Zhu, D Qiao - Molecules, 2022 - mdpi.com
Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through
interfering with the normal structure and function of microtubules, forming spindle filaments …

New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation

J Lin, D Xiao, L Lu, B Liang, Z Xiong, X Xu - Journal of Molecular Structure, 2023 - Elsevier
Abstract α-Glucosidase is an important therapeutic target of diabetes mellitus. To find potent
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …

Natural and synthetic β-carboline as a privileged antifungal scaffolds

JK Dai, WJ Dan, JB Wan - European Journal of Medicinal Chemistry, 2022 - Elsevier
The discovery of antifungal agents with novel structure, broad-spectrum, low toxicity, and
high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline …

Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies

JP Soni, GN Reddy, Z Rahman, A Sharma… - Bioorganic …, 2023 - Elsevier
In a quest for effective cancer targeted drug therapy, a series of new β-carboline tethered
indole-3-glyoxylamide derivatives, conjoining salient pharmacophoric properties with …

Harmicens, novel harmine and ferrocene hybrids: design, synthesis and biological activity

G Poje, M Marinović, K Pavić, M Mioč, M Kralj… - International journal of …, 2022 - mdpi.com
Cancer and malaria are both global health threats. Due to the increase in the resistance to
the known drugs, research on new active substances is a priority. Here, we present the …

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

PP Tshikhudo, T Mabhaudhi… - Chemistry & …, 2024 - Wiley Online Library
Abstract his comprehensive review is designed to evaluate the anticancer properties of β‐
carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability …

Rh (III)-catalysed site-selective alkylation of β-carbolines/isoquinolines and tandem CH/CN functionalization to construct indolizine-indole frameworks

D Bora, SE John, MS Galla, M Sathish… - Molecular Catalysis, 2022 - Elsevier
The rhodium-catalysed ortho-selective carbenes insertion strategy to activate the non-acidic
sp 2 Csingle bondH bond of β-carboline and isoquinoline scaffolds was developed. This …

Regioselective ortho‐sulfonamidation: Exploration of Intrinsic Directing Property of β‐Carbolines and their Photophysical Studies

D Bora, S Reddy Dannarm, S Elza John… - Asian Journal of …, 2021 - Wiley Online Library
A regioselective ruthenium‐catalysed strategy for synthesising mono‐, ortho‐
sulfonamidated β‐carboline derivatives using sulfonyl azide was accomplished by relying …

Exploration of benzimidazoles as potential microtubule modulators: An insight in the synthetic and therapeutic evolution

K Laxmikeshav, A Himaja, N Shankaraiah - Journal of Molecular Structure, 2022 - Elsevier
The dynamic microtubules are one of the most fruitful targets for cancer chemotherapy. The
outcomes of various studies depict that the benzimidazole framework is a fundamental …