Renaissance of protein crystallization and precipitation in biopharmaceuticals purification
The current chromatographic approaches used in protein purification are not keeping pace
with the increasing biopharmaceutical market demand. With the upstream improvements …
with the increasing biopharmaceutical market demand. With the upstream improvements …
Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation
R Abdella, M Aggarwal, T Okura… - Proceedings of the …, 2020 - National Acad Sciences
Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a
wide spectrum of human and animal diseases. The viral genome, packaged by the …
wide spectrum of human and animal diseases. The viral genome, packaged by the …
Recombinant soluble respiratory syncytial virus F protein that lacks heptad repeat B, contains a GCN4 trimerization motif and is not cleaved displays prefusion-like …
I Widjaja, A Rigter, S Jacobino, FJM van Kuppeveld… - PloS one, 2015 - journals.plos.org
The respiratory syncytial virus (RSV) fusion protein F is considered an attractive vaccine
candidate especially in its prefusion conformation. We studied whether recombinant soluble …
candidate especially in its prefusion conformation. We studied whether recombinant soluble …
Flexibility of the head-stalk linker domain of paramyxovirus HN glycoprotein is essential for triggering virus fusion
E Adu-Gyamfi, LS Kim, TS Jardetzky… - Journal of virology, 2016 - Am Soc Microbiol
The Paramyxoviridae comprise a large family of enveloped, negative-sense, single-stranded
RNA viruses with significant economic and public health implications. For nearly all …
RNA viruses with significant economic and public health implications. For nearly all …
Novel Mammalian orthorubulavirus 5 Discovered as Accidental Cell Culture Contaminant
A distinct Russian Mammalian orthorubulavirus 5 (PIV5) was detected in cell culture
exhibiting cytopathic effect and hypothesized to be contaminated by a scientist with …
exhibiting cytopathic effect and hypothesized to be contaminated by a scientist with …
Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins
Parainfluenza virus 5 (PIV5) is an enveloped, single-stranded, negative-sense RNA virus of
the Paramyxoviridae family. PIV5 fusion and entry are mediated by the coordinated action of …
the Paramyxoviridae family. PIV5 fusion and entry are mediated by the coordinated action of …
Cryogenic-Electron Microscopy Structures of Viral and Eukaryotic Transcription Complexes
R Abdella - 2021 - search.proquest.com
Transcription of nucleic acids (DNA and RNA) is a hallmark of life, taking the information
stored within genomic nucleic acids and converting it into a form that is useful for producing …
stored within genomic nucleic acids and converting it into a form that is useful for producing …
Developing non-chromatographic strategies for biopharmaceuticals purification
RAR dos Santos - 2020 - search.proquest.com
The biopharmaceutical market shows a high annual growth, and the major contributors for
this success are antibody molecules. The purification of high added value biological …
this success are antibody molecules. The purification of high added value biological …
Interferon induction by paramyxoviruses: investigations into specific RNA: protein interactions
F Dominguez Palao - 2017 - research-repository.st-andrews.ac …
RNA: protein interactions are central in many cellular processes, including activation of
innate immune responses against microbial infection. Their study is essential to better …
innate immune responses against microbial infection. Their study is essential to better …