The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …

Astrocytes protect neurons by modulating neuronal function and survival. Astrocytes support
neurons in several ways. They provide energy through the astrocyte-neuron lactate shuttle …

Used as a supplement to psychotherapy, pharmacotherapy that addresses all of the known
metabolic and genetic contributions to the pathogenesis of psychiatric conditions caused by …

Background: rTg4510 mice are transgenic mice expressing P301L mutant tau and have
been developed as an animal model of tauopathy including Alzheimer's Disease (AD) …

Background Pharmacotherapy for most psychiatric conditions was developed from
serendipitous observations of benefit from drugs prescribed for different reasons. An …

N-methyl-D-aspartate receptors (NMDARs) are glutamate receptors with key roles in
synaptic communication and plasticity. The activation of synaptic NMDARs initiates plasticity …

Аннотация Расстройства аутистического спектра (РАС)—это нарушения психического
развития, характеризующиеся снижением социального взаимодействия и …

冈田酸(OA) 是一种强聚醚海洋毒素, 能抑制蛋白磷酸酯酶-1 (PP1), 蛋白磷酸酯酶-2A (PP2A)
活性, 促使tau 蛋白过度磷酸化. 根据该特性以及利用OA 造模操作简单, 成本低 …

In the last decade, the onset of neurodegenerative diseases (ND) has been strongly
widespread due to the rapid increase in the world population. There are many …