Targeted drug delivery strategies for precision medicines

MT Manzari, Y Shamay, H Kiguchi, N Rosen… - Nature Reviews …, 2021 - nature.com
Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Targeting strategies for tissue-specific drug delivery

Z Zhao, A Ukidve, J Kim, S Mitragotri - Cell, 2020 - cell.com
Off-target effects of systemically administered drugs have been a major hurdle in designing
therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to …

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

JD Martin, H Cabral, T Stylianopoulos… - Nature reviews Clinical …, 2020 - nature.com
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Nanotechnology for boosting cancer immunotherapy and remodeling tumor microenvironment: the horizons in cancer treatment

S Gao, X Yang, J Xu, N Qiu, G Zhai - ACS nano, 2021 - ACS Publications
Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

Active targeting strategies using biological ligands for nanoparticle drug delivery systems

J Yoo, C Park, G Yi, D Lee, H Koo - Cancers, 2019 - mdpi.com
Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as
drug delivery systems. Along with optimization of physicochemical properties, researchers …

Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa

KA Khan, RS Kerbel - Nature Reviews Clinical Oncology, 2018 - nature.com
Immunotherapies have revolutionized medical oncology following the remarkable and, in
some cases, unprecedented outcomes observed in certain groups of patients with cancer …

mRNA vaccine for cancer immunotherapy

L Miao, Y Zhang, L Huang - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have become a promising platform for cancer immunotherapy.
During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …

Biomembrane-based nanostructures for cancer targeting and therapy: from synthetic liposomes to natural biomembranes and membrane-vesicles

J Wang, M Zhu, G Nie - Advanced drug delivery reviews, 2021 - Elsevier
The translational success of liposomes in chemotherapeutics has already demonstrated the
great potential of biomembrane-based nanostructure in effective drug delivery. Meanwhile …

Nanoengineered immune niches for reprogramming the immunosuppressive tumor microenvironment and enhancing cancer immunotherapy

H Phuengkham, L Ren, IW Shin, YT Lim - Advanced Materials, 2019 - Wiley Online Library
Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …

Neutrophil‐based drug delivery systems

D Chu, X Dong, X Shi, C Zhang, Z Wang - Advanced materials, 2018 - Wiley Online Library
White blood cells (WBCs) are a major component of immunity in response to pathogen
invasion. Neutrophils are the most abundant WBCs in humans, playing a central role in …