Multidrug efflux pumps: structure, function and regulation

D Du, X Wang-Kan, A Neuberger… - Nature Reviews …, 2018 - nature.com
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …

Bacterial resistance to antimicrobial agents

MF Varela, J Stephen, M Lekshmi, M Ojha, N Wenzel… - Antibiotics, 2021 - mdpi.com
Bacterial pathogens as causative agents of infection constitute an alarming concern in the
public health sector. In particular, bacteria with resistance to multiple antimicrobial agents …

Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria

I Alav, J Kobylka, MS Kuth, KM Pos, M Picard… - Chemical …, 2021 - ACS Publications
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

The food production environment and the development of antimicrobial resistance in human pathogens of animal origin

M Lekshmi, P Ammini, S Kumar, MF Varela - Microorganisms, 2017 - mdpi.com
Food-borne pathogens are a serious human health concern worldwide, and the emergence
of antibiotic-resistant food pathogens has further confounded this problem. Once-highly …

Functional and structural roles of the major facilitator superfamily bacterial multidrug efflux pumps

S Kumar, M Lekshmi, A Parvathi, M Ojha, N Wenzel… - Microorganisms, 2020 - mdpi.com
Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public
health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator …

[HTML][HTML] Biochemical and molecular mechanisms of antibiotic resistance in Salmonella spp.

R Chaudhari, K Singh, P Kodgire - Research in Microbiology, 2023 - Elsevier
Salmonella is a diverse Gram-negative bacterium that represents the major disease burden
worldwide. According to WHO, Salmonella is one of the fourth global causes of diarrhoeal …

The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus

J Stephen, F Salam, M Lekshmi, SH Kumar, MF Varela - Antibiotics, 2023 - mdpi.com
The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public
health concern for centuries. Throughout its evolutionary course, S. aureus has developed …

Epidemiology of efflux pumps genes mediating resistance among Staphylococcus aureus; A systematic review

S Hassanzadeh, MR Pourmand, R Mashhadi… - Microbial …, 2020 - Elsevier
Background Efflux of antibiotics is an effective resistance mechanism among antibiotic-
resistant Staphylococcus aureus. This systematic review aims to evaluate the frequency and …

Inhibition of multidrug efflux pumps belonging to the major facilitator superfamily in bacterial pathogens

MF Varela, J Stephen, D Bharti, M Lekshmi, S Kumar - Biomedicines, 2023 - mdpi.com
Bacterial pathogens resistant to multiple structurally distinct antimicrobial agents are
causative agents of infectious disease, and they thus constitute a serious concern for public …

Promising FDA-approved drugs with efflux pump inhibitory activities against clinical isolates of Staphylococcus aureus

SAAM Abdel-Karim, AMA El-Ganiny, MA El-Sayed… - Plos one, 2022 - journals.plos.org
Background and objectives Staphylococcus aureus is an opportunistic pathogen that causes
wide range of nosocomial and community-acquired infections which have spread worldwide …