In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …

The number of people aged over 65 is expected to double in the next 30 years. For many,
living longer will mean spending more years with the burdens of chronic diseases such as …

Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …

Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet
how and when obesity contributes to PDAC progression is not well understood. Leveraging …

At present, proven clinical treatments but no cures are available for diabetes, a global
epidemic with a huge economic burden. Transplantation of islets of Langerhans by their …

Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In
mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which …

The substantially increased prevalence of obesity and obesity-related diseases has
generated considerable concern. Currently, synthetic biological strategies have played an …

Cholecystokinin (CCK) is a hormone secreted from I-cells of the gut, as well as neurons in
the enteric and central nervous system, that binds and activates CCK-1 and CCK-2 …