The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

Management of nasopharyngeal carcinoma: current practice and future perspective

AWM Lee, BBY Ma, WT Ng, ATC Chan - Journal of clinical oncology, 2015 - ascopubs.org
Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China,
and patient prognosis has improved significantly over the past three decades because of …

Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma

Y Zhang, L Chen, GQ Hu, N Zhang… - … England Journal of …, 2019 - Mass Medical Soc
Background Platinum-based concurrent chemoradiotherapy is the standard of care for
patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine …

Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised …

YP Chen, X Liu, Q Zhou, KY Yang, F Jin, XD Zhu, M Shi… - The Lancet, 2021 - thelancet.com
Background Patients with locoregionally advanced nasopharyngeal carcinoma have a high
risk of disease relapse, despite a high proportion of patients attaining complete clinical …

Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and …

ZQ Zheng, ZX Li, GQ Zhou, L Lin, LL Zhang, JW Lv… - Cancer research, 2019 - AACR
Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression
of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms …

Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a …

Y Sun, WF Li, NY Chen, N Zhang, GQ Hu, FY Xie… - The lancet …, 2016 - thelancet.com
Background The value of adding cisplatin, fluorouracil, and docetaxel (TPF) induction
chemotherapy to concurrent chemoradiotherapy in locoregionally advanced …

Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

P Bossi, AT Chan, L Licitra, A Trama… - Annals of …, 2021 - annalsofoncology.org
Nasopharyngeal carcinoma (NPC) is a disease with unique epidemiological features. The
distribution of the disease demonstrates a clear regional, racial and gender prevalence. In …

Prognostic value of deep learning PET/CT-based radiomics: potential role for future individual induction chemotherapy in advanced nasopharyngeal carcinoma

H Peng, D Dong, MJ Fang, L Li, LL Tang, L Chen… - Clinical Cancer …, 2019 - AACR
Purpose: We aimed to evaluate the value of deep learning on positron emission tomography
with computed tomography (PET/CT)–based radiomics for individual induction …

Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre …

LL Tang, CL Huang, N Zhang, W Jiang, YS Wu… - The Lancet …, 2022 - thelancet.com
Background The aim of this trial was to address whether elective ipsilateral upper-neck
irradiation (UNI) sparing the uninvolved lower neck provides similar regional relapse-free …

International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma

AW Lee, WT Ng, JJ Pan, SS Poh, YC Ahn… - Radiotherapy and …, 2018 - Elsevier
Purpose Target delineation in nasopharyngeal carcinoma (NPC) often proves challenging
because of the notoriously narrow therapeutic margin. High doses are needed to achieve …