Intra-pancreatic fat deposition: bringing hidden fat to the fore

MS Petrov, R Taylor - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Abstract Development of advanced modalities for detection of fat within the pancreas has
transformed understanding of the role of intra-pancreatic fat deposition (IPFD) in health and …

Metabolic implications of pancreatic fat accumulation

R Wagner, SS Eckstein, H Yamazaki, F Gerst… - Nature Reviews …, 2022 - nature.com
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

Adipose tissue expandability, lipotoxicity and the metabolic syndrome—an allostatic perspective

S Virtue, A Vidal-Puig - Biochimica et Biophysica Acta (BBA)-molecular and …, 2010 - Elsevier
While the link between obesity and type 2 diabetes is clear on an epidemiological level, the
underlying mechanism linking these two common disorders is not as clearly understood …

Ectopic fat accumulation in the pancreas and its clinical relevance: a systematic review, meta-analysis, and meta-regression

RG Singh, HD Yoon, LM Wu, J Lu, LD Plank, MS Petrov - Metabolism, 2017 - Elsevier
Objective Growing evidence suggests that individuals with excessive fat in the pancreas are
at an increased risk of chronic metabolic disorders. The aim was to systematically review …

[HTML][HTML] Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

R Catanzaro, B Cuffari, A Italia… - World journal of …, 2016 - ncbi.nlm.nih.gov
After the first description of fatty pancreas in 1933, the effects of pancreatic steatosis have
been poorly investigated, compared with that of the liver. However, the interest of research is …

Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic …

A Dutour, I Abdesselam, P Ancel… - Diabetes, Obesity …, 2016 - Wiley Online Library
Aim To conduct a prospective randomized trial to investigate the effect of glucagon‐like
peptide‐1 (GLP‐1) analogues on ectopic fat stores. Methods A total of 44 obese subjects …

Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women

O Fiehn, WT Garvey, JW Newman, KH Lok, CL Hoppel… - PloS one, 2010 - journals.plos.org
Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad
perturbation of macronutrient intermediary metabolism. Understanding the biochemical …

The clinical significance of pancreatic steatosis

MM Smits, EJM Van Geenen - Nature reviews Gastroenterology & …, 2011 - nature.com
More research is now focused on pancreatic steatosis. Multiple definitions, clinical
associations and synonyms for pancreatic steatosis are described in the literature and can …

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

RH Unger, PE Scherer - Trends in Endocrinology & Metabolism, 2010 - cell.com
Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome)
are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and …

Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots

S Hocking, D Samocha-Bonet, KL Milner… - Endocrine …, 2013 - academic.oup.com
Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …