The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this
Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …