Cardiac rhythm is extremely robust, generating 2 billion contraction cycles during the
average human life span. Transcriptional control of cardiac rhythm is poorly understood. We …

Atrial fibrillation (AF) is a complex disease that results from genetic and environmental
factors and their interactions. In recent years, genome-wide association studies (GWAS) and …

Atrial fibrillation (AF), defined by disorganized atrial cardiac rhythm, is the most prevalent
cardiac arrhythmia worldwide. Recent genetic studies have highlighted a major heritable …

The cardiac T-box transcription factor TBX5 is crucial for proper cardiovascular
development, and mutations in TBX5 have been associated with various congenital heart …

Aims Atrial fibrillation (AF) is a common arrhythmia with an important heritable aspect. The
genetic factors underlying AF have not been fully elucidated. Methods and results We …

Aims MOG1 is a small protein that can bind to small GTPase RAN and regulate transport of
RNA and proteins between the cytoplasm and nucleus. However, the in vivo physiological …

Previous genome-wide association studies have demonstrated that single nucleotide
polymorphisms in T‑box (TBX) 5 are associated with increased susceptibility to atrial …

Transcription factors TBX5 and PITX2 involve in the regulation of gene expression of ion
channels and are closely associated with atrial fibrillation (AF), the most common cardiac …

TBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent
manner. But little is known about the potential association of TBX5 3′ untranslated region …

The term idiopathic or lone atrial fibrillation (AF) is commonly used in the young and
apparently healthy individual who suffers from AF. Although there is conflicting evidence …