Voltage-gated ion channels generate electrical signals in species from bacteria to man.
Their voltage-sensing modules are responsible for initiation of action potentials and graded …

The number of membrane protein structures in the Protein Data Bank is becoming significant
and growing. Here, the transmembrane domain structures of the helical membrane proteins …

Voltage-gated ion channels play a central role in the generation of action potentials in the
nervous system. They are selective for one type of ion–sodium, calcium, or potassium …

The heptameric mechanosensitive channel of small conductance (MscS) provides a critical
function in Escherichia coli where it opens in response to increased bilayer tension. Three …

Voltage-gated sodium channels (Na V s) provide the initial electrical signal that drives action
potential generation in many excitable cells of the brain, heart, and nervous system. For …

The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation
that underlies a wide range of physiological functions, including the phagocytic respiratory …

Voltage-sensor domains couple membrane potential to conformational changes in voltage-
gated ion channels and phosphatases. Highly coevolved acidic and aromatic side chains …

A conformational selection method, based on hydrogen bond (Hbond) network analysis, has
been designed in order to rationalize the configurations sampled using molecular dynamics …

Tim23, the central subunit of the TIM23 protein-translocation complex, forms a voltage-gated
channel in the mitochondrial inner membrane (MIM), an energy-conserving membrane that …

Voltage-gated ion channels respond to transmembrane electric fields through reorientations
of the positively charged S4 helix within the voltage-sensing domain (VSD). Despite a …