Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

PCM van Zijl, K Brindle, H Lu, PB Barker… - Current opinion in …, 2021 - Elsevier
Access to metabolic information in vivo using magnetic resonance (MR) technologies has
generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI) …

Brain oxygen extraction is differentially altered by Alzheimer's and vascular diseases

D Jiang, Z Lin, P Liu, S Sur, C Xu… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their
concurrence, represent the most common types of cognitive dysfunction. Treatment …

[HTML][HTML] MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe

D Jiang, P Liu, Z Lin, K Hazel, G Pottanat, E Lucke… - NeuroImage, 2023 - Elsevier
The medial temporal lobe (MTL) is a key area implicated in many brain diseases, such as
Alzheimer's disease. As a functional biomarker, the oxygen extraction fraction (OEF) of MTL …

Multi‐parametric evaluation of cerebral hemodynamics in neonatal piglets using non‐contrast‐enhanced magnetic resonance imaging methods

D Liu, D Jiang, A Tekes, E Kulikowicz… - Journal of Magnetic …, 2021 - Wiley Online Library
Background Disruption of brain oxygen delivery and consumption after hypoxic–ischemic
injury contributes to neonatal mortality and neurological impairment. Measuring cerebral …

[HTML][HTML] Brain oxygen extraction and metabolism in pediatric patients with sickle cell disease: comparison of four calibration models

Z Lin, T McIntyre, D Jiang, A Cannon, P Liu… - Frontiers in …, 2022 - frontiersin.org
Sickle cell disease (SCD) is an inherited hemoglobinopathy with an increased risk of
neurological complications. Due to anemia and other factors related to the underlying …

Preterm infants variability in cerebral near-infrared spectroscopy measurements in the first 72-h after birth

SE Kolnik, R Marquard, O Brandon… - Pediatric …, 2023 - nature.com
Background Cerebral near-infrared spectroscopy is a non-invasive tool used to measure
regional cerebral tissue oxygenation (rScO2) initially validated in adult and pediatric …

[HTML][HTML] Brain Frontal-Lobe Misery Perfusion in COVID-19 ICU Survivors: An MRI Pilot Study

J Song, S Khanduja, H Rando, W Shi, K Hazel… - Brain Sciences, 2024 - mdpi.com
Post-acute COVID-19 syndrome (PCS) is highly prevalent. Critically ill patients requiring
intensive care unit (ICU) admission are at a higher risk of developing PCS. The mechanisms …

Vessel‐specific quantification of cerebral venous oxygenation with velocity‐encoding preparation and rapid acquisition

Z Lin, D Jiang, Y Hong, Y Zhang… - Magnetic resonance …, 2024 - Wiley Online Library
Purpose Non‐invasive measurement of cerebral venous oxygenation (Yv) is of critical
importance in brain diseases. The present work proposed a fast method to quantify regional …

Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded‐O2 study in piglets

D Jiang, RC Koehler, X Liu, E Kulikowicz… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To validate two neonatal cerebral venous oxygenation (Yv) MRI techniques, T2
relaxation under phase contrast (TRUPC) and accelerated TRUPC (aTRUPC) MRI, with …