Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …

Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and
pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely …

The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus
(HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which …

Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1
E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial …

There are no effective cures for upper motor neuron (UMN) diseases, such as amyotrophic
lateral sclerosis (ALS), primary lateral sclerosis, and hereditary spastic paraplegia. Here, we …

Sarcopenia involves in the loss of muscle mass associated with aging, which is the major
cause of progressive muscle weakness and deterioration in older adults. Muscle atrophy is a …

Intrauterine growth restriction (IUGR) occurs in 15–20% of pig neonates and poses huge
economic losses to the pig industry. IUGR piglets have reduced skeletal muscle growth …

The survival of motor neuron (SMN) protein is a major component of the pre-mRNA splicing
machinery and is required for RNA metabolism. Although SMN has been considered a …

Most proteins maintain protein homeostasis via post‑translational modifications, including
the ubiquitin‑proteasome system. Deubiquitinating enzymes (DUBs) have essential …

Facioscapulohumeral muscular dystrophy (FSHD) represents the third most common form of
muscular dystrophy and is characterized by muscle weakness and atrophy. FSHD is caused …