Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly
all kinds of neurological diseases. These activated microglia become highly motile …

Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …

A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849
controls identified eight previously reported AD risk loci and 14 novel loci associated with …

It is well accepted that CNS inflammation has a role in the progression of chronic
neurodegenerative disease, although the mechanisms through which this occurs are still …

Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …

Research into the function of microglia has dramatically accelerated during the last few
years, largely due to recent genetic findings implicating microglia in virtually every …

Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a
widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
decline of cognitive function. There is no therapy that can halt or reverse its progression …

One hundred and fifty years have elapsed since the original discovery of the microglial cell
by Virchow. While this cell type has been well studied, the role of microglia in the pathology …