Malaria: biology and disease
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …
cause of death and disease across many tropical and subtropical countries. Over the last …
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects
AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …
of the world population is still exposed to the risk of contracting malaria. Developing an …
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …
organisms with distinct morphological developmental stages each specialized to inhabit …
Role of host cell traversal by the malaria sporozoite during liver infection
J Tavares, P Formaglio, S Thiberge… - Journal of experimental …, 2013 - rupress.org
Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into
the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a …
the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a …
The silent path to thousands of merozoites: the Plasmodium liver stage
Plasmodium sporozoites are deposited in the skin of their vertebrate hosts through the bite
of an infected female Anopheles mosquito. Most of these parasites find a blood vessel and …
of an infected female Anopheles mosquito. Most of these parasites find a blood vessel and …
Malaria parasite development in the mosquito and infection of the mammalian host
ASI Aly, AM Vaughan, SHI Kappe - Annual review of …, 2009 - annualreviews.org
Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …
The development of malaria parasites in the mosquito midgut
The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
P Pino, R Caldelari, B Mukherjee, J Vahokoski… - Science, 2017 - science.org
Regulated exocytosis by secretory organelles is important for malaria parasite invasion and
egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are …
egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are …
Malaria sporozoites traverse host cells within transient vacuoles
V Risco-Castillo, S Topçu, C Marinach, G Manzoni… - Cell host & …, 2015 - cell.com
Plasmodium sporozoites are deposited in the host skin by Anopheles mosquitoes. The
parasites migrate from the dermis to the liver, where they invade hepatocytes through a …
parasites migrate from the dermis to the liver, where they invade hepatocytes through a …