The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands
and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI) …

Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth
and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. In a …

Major depression, with its strikingly high prevalence, is the most common cause of disability
in communities of Western type, according to data of the World Health Organization. Stress …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Anxiety disorders are common, serious and a growing health problem worldwide. However,
the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most …

Neuropathic pain is a complex chronic condition characterized by various sensory,
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …

Background: Dysregulated stress neurocircuits, caused by genetic and/or environmental
changes, underlie the development of many neuropsychiatric disorders. Corticotropin …

Corticotropin-releasing hormone (CRH) plays a major role in coordinating the behavioral,
endocrine, autonomic and immune responses to stress. CRH and CRH-related peptides and …

Brain-derived neurotrophic factor (BDNF) has multiple roles in the central nervous system
(CNS), including maintaining cell survival and regulation of synaptic function. In CNS …