Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Molecular imaging and disease theranostics with renal-clearable optical agents

P Cheng, K Pu - Nature Reviews Materials, 2021 - nature.com
Optical imaging in disease diagnosis and treatment benefits from high spatiotemporal
resolution and the availability of numerous optical agents. However, many optical imaging …

Supramolecular cancer nanotheranostics

J Zhou, L Rao, G Yu, TR Cook, X Chen… - Chemical Society …, 2021 - pubs.rsc.org
Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …

Near‐infrared‐II molecular dyes for cancer imaging and surgery

S Zhu, R Tian, AL Antaris, X Chen, H Dai - Advanced Materials, 2019 - Wiley Online Library
Fluorescence bioimaging affords a vital tool for both researchers and surgeons to
molecularly target a variety of biological tissues and processes. This review focuses on …

Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

J Li, K Pu - Chemical Society Reviews, 2019 - pubs.rsc.org
Biophotonics as a highly interdisciplinary frontier often requires the assistance of optical
agents to control the light pathways in cells, tissues and living organisms for specific …

Size‐dependent EPR effect of polymeric nanoparticles on tumor targeting

H Kang, S Rho, WR Stiles, S Hu, Y Baek… - Advanced …, 2020 - Wiley Online Library
Passive targeting of large nanoparticles by the enhanced permeability and retention (EPR)
effect is a crucial concept for solid tumor targeting in cancer nanomedicine. There is …

Ultra‐Small Nano‐Assemblies as Tumor‐Targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy

D Zhang, KX Teng, L Zhao, LY Niu… - Advanced …, 2023 - Wiley Online Library
It is a challenge to design photosensitizers to balance between the tumor‐targeting
enrichment for precise treatment and efficient clearance within a reasonable timescale for …

Transport and interactions of nanoparticles in the kidneys

B Du, M Yu, J Zheng - Nature Reviews Materials, 2018 - nature.com
Kidneys are a major organ for blood filtration and waste elimination and thus play a key role
in the transport and clearance of nanoparticles in vivo. The interactions of nanoparticles with …

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Y Pan, W Tang, W Fan, J Zhang, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Hyaluronic acid and albumin based nanoparticles for drug delivery

C Lei, XR Liu, QB Chen, Y Li, JL Zhou, LY Zhou… - Journal of Controlled …, 2021 - Elsevier
Albumin, a multifunctional protein, is widely used to prepare nanocarriers. Hyaluronic acid
(HA) is a natural glycosaminoglycan that can specifically bind receptors, such as cluster of …