The combination of laser photodissociation, action spectroscopy, and mass spectrometry to identify and separate isomers

SJP Marlton, AJ Trevitt - Chemical Communications, 2022 - pubs.rsc.org
The separation and detection of isomers remains a challenge for many areas of mass
spectrometry. This article highlights laser photodissociation and ion mobility strategies that …

Lipid analysis by mass spectrometry coupled with laser light

C Kirschbaum, K Pagel - Analysis & Sensing, 2023 - Wiley Online Library
Lipids are small but complex biomolecules that feature an immense structural and functional
diversity. The molecular structure and biological functions of lipids are intricately linked …

Mass-spectrometry-based identification of synthetic drug isomers using infrared ion spectroscopy

RF Kranenburg, FAMG van Geenen, G Berden… - Analytical …, 2020 - ACS Publications
Infrared ion spectroscopy (IRIS), a mass-spectrometry-based technique exploiting resonant
infrared multiple photon dissociation (IRMPD), has been applied for the identification of …

Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

RE van Outersterp, SJ Moons, UFH Engelke… - Communications …, 2021 - nature.com
The identification of disease biomarkers plays a crucial role in developing diagnostic
strategies for inborn errors of metabolism and understanding their pathophysiology. A …

Isomer-Specific Two-Color Double-Resonance IR2MS3 Ion Spectroscopy Using a Single Laser: Application in the Identification of Novel Psychoactive Substances

FAMG van Geenen, RF Kranenburg… - Analytical …, 2021 - ACS Publications
The capability of an ion trap mass spectrometer to store ions for an arbitrary amount of time
allows the use of a single infrared (IR) laser to perform two-color double resonance IR–IR …

Evaluation of table-top lasers for routine infrared ion spectroscopy in the analytical laboratory

RE van Outersterp, J Martens, A Peremans, L Lamard… - Analyst, 2021 - pubs.rsc.org
Infrared ion spectroscopy is increasingly recognized as a method to identify mass
spectrometry-detected analytes in many (bio) chemical areas and its integration in analytical …

Targeted Small-Molecule Identification Using Heartcutting Liquid Chromatography–Infrared Ion Spectroscopy

RE van Outersterp, J Oosterhout, CR Gebhardt… - Analytical …, 2023 - ACS Publications
Infrared ion spectroscopy (IRIS) can be used to identify molecular structures detected in
mass spectrometry (MS) experiments and has potential applications in a wide range of …

Preferred protonation site of a series of sulfa drugs in the gas phase revealed by IR spectroscopy

T Uhlemann, G Berden, J Oomens - The European Physical Journal D, 2021 - Springer
Sulfa drugs are an important class of pharmaceuticals in the treatment of bacterial infections.
The amido/imido tautomerism of these molecules in their neutral form has been widely …

[HTML][HTML] High-Throughput UV Photoionization and Fragmentation of Neutral Biomolecules as a Structural Fingerprint

S Wang, Y Dauletyarov, DA Horke - Molecules, 2023 - mdpi.com
We present UV photofragmentation studies of the structural isomers paracetamol, 3-
Pyridinepropionic acid (3-PPIA) and (R)-(-)-2-Phenylglycine. In particular, we utilized a new …

Instrument-independent chemometric models for rapid, calibration-free NPS isomer differentiation from mass spectral GC-MS data

JL Bonetti, RF Kranenburg, E Schoonderwoerd… - Forensic Science …, 2023 - Elsevier
Chemometric analysis of mass spectral data for the purpose of differentiating positional
isomers of novel psychoactive substances has seen a substantial increase in popularity in …