Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells
The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …
Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …
[PDF][PDF] Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine
C Kurematsu, M Sawada, M Ohmuraya… - Journal of Experimental …, 2022 - rupress.org
New neurons, continuously added in the adult olfactory bulb (OB) and hippocampus, are
involved in information processing in neural circuits. Here, we show that synaptic pruning of …
involved in information processing in neural circuits. Here, we show that synaptic pruning of …
A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis
E Lee, YJ Jung, YR Park, S Lim, YJ Choi, SY Lee… - Nature aging, 2022 - nature.com
The aging brain exhibits a region-specific reduction in synapse number and plasticity.
Although astrocytes play central roles in regulating synapses, it is unclear how changes in …
Although astrocytes play central roles in regulating synapses, it is unclear how changes in …
Phagocytic astrocytes: emerging from the shadows of microglia
Elimination of dead or live cells take place in both a healthy and diseased central nervous
system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance …
system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance …
[PDF][PDF] Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis
Childhood neglect and/or abuse can induce mental health conditions with unknown
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …
Phosphatidylserine transport in cell life and death
Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …
Astrocyte-dependent circuit remodeling by synapse phagocytosis
J Park, WS Chung - Current Opinion in Neurobiology, 2023 - Elsevier
In the central nervous system, synaptic pruning, the removal of unnecessary synaptic
contacts, is an essential process for proper circuit maturation in neurodevelopment as well …
contacts, is an essential process for proper circuit maturation in neurodevelopment as well …