Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells

Y Liu, X Shen, Y Zhang, X Zheng, C Cepeda, Y Wang… - Glia, 2023 - Wiley Online Library
The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …

Targeting synapse function and loss for treatment of neurodegenerative diseases

B Dejanovic, M Sheng, JE Hanson - Nature Reviews Drug Discovery, 2024 - nature.com
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models

B Dejanovic, T Wu, MC Tsai, D Graykowski… - Nature aging, 2022 - nature.com
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

[PDF][PDF] Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses

JL Bolton, AK Short, S Othy, CL Kooiker, M Shao… - Cell reports, 2022 - cell.com
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …

Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine

C Kurematsu, M Sawada, M Ohmuraya… - Journal of Experimental …, 2022 - rupress.org
New neurons, continuously added in the adult olfactory bulb (OB) and hippocampus, are
involved in information processing in neural circuits. Here, we show that synaptic pruning of …

A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

E Lee, YJ Jung, YR Park, S Lim, YJ Choi, SY Lee… - Nature aging, 2022 - nature.com
The aging brain exhibits a region-specific reduction in synapse number and plasticity.
Although astrocytes play central roles in regulating synapses, it is unclear how changes in …

Phagocytic astrocytes: emerging from the shadows of microglia

H Konishi, S Koizumi, H Kiyama - Glia, 2022 - Wiley Online Library
Elimination of dead or live cells take place in both a healthy and diseased central nervous
system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance …

[PDF][PDF] Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis

YG Byun, NS Kim, G Kim, YS Jeon, JB Choi, CW Park… - Immunity, 2023 - cell.com
Childhood neglect and/or abuse can induce mental health conditions with unknown
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …

Phosphatidylserine transport in cell life and death

A Čopič, T Dieudonné, G Lenoir - Current Opinion in Cell Biology, 2023 - Elsevier
Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …

Astrocyte-dependent circuit remodeling by synapse phagocytosis

J Park, WS Chung - Current Opinion in Neurobiology, 2023 - Elsevier
In the central nervous system, synaptic pruning, the removal of unnecessary synaptic
contacts, is an essential process for proper circuit maturation in neurodevelopment as well …