Pharmacological properties of trichostatin A, focusing on the anticancer potential: A comprehensive review
A Bouyahya, N El Omari, M Bakha, T Aanniz… - Pharmaceuticals, 2022 - mdpi.com
Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …
Introducing HDAC-targeting radiopharmaceuticals for glioblastoma imaging and therapy
L Everix, EN Seane, T Ebenhan, I Goethals, J Bolcaen - Pharmaceuticals, 2023 - mdpi.com
Despite recent advances in multimodality therapy for glioblastoma (GB) incorporating
surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains …
surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains …
Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury
J Thangavel, S Samanta, S Rajasingh… - Journal of cell …, 2015 - journals.biologists.com
Acute lung injury (ALI) during sepsis is characterized by bilateral alveolar infiltrates, lung
edema and respiratory failure. Here, we examined the efficacy the DNA methyl transferase …
edema and respiratory failure. Here, we examined the efficacy the DNA methyl transferase …
Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine
M Staberg, SR Michaelsen, RD Rasmussen… - Cellular Oncology, 2017 - Springer
Purpose Glioblastoma (GBM) ranks among the deadliest solid cancers worldwide and its
prognosis has remained dismal, despite the use of aggressive chemo-irradiation treatment …
prognosis has remained dismal, despite the use of aggressive chemo-irradiation treatment …
Advances in histone deacetylase inhibitors in targeting glioblastoma stem cells
RG Reddy, UA Bhat, S Chakravarty… - Cancer Chemotherapy and …, 2020 - Springer
Glioblastoma multiforme (GBM) is a lethal grade IV glioma (WHO classification) and widely
prevalent primary brain tumor in adults. GBM tumors harbor cellular heterogeneity with the …
prevalent primary brain tumor in adults. GBM tumors harbor cellular heterogeneity with the …
Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA
HDAC class IIa enzymes (HDAC4, 5, 7, 9) are important for glioma progression, invasion,
responses to TMZ and radiotherapy, and prognosis. In this study, we demonstrated the …
responses to TMZ and radiotherapy, and prognosis. In this study, we demonstrated the …
[HTML][HTML] Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory …
Impairment of tissue fluid homeostasis and migration of inflammatory cells across the
vascular endothelial barrier are crucial factors in the pathogenesis of acute lung injury (ALI) …
vascular endothelial barrier are crucial factors in the pathogenesis of acute lung injury (ALI) …
Molecular mechanisms of vascular damage during lung injury
R Bossardi Ramos, AP Adam - Lung Inflammation in Health and Disease …, 2021 - Springer
A variety of pulmonary and systemic insults promote an inflammatory response causing
increased vascular permeability, leading to the development of acute lung injury (ALI), a …
increased vascular permeability, leading to the development of acute lung injury (ALI), a …
Combination therapy with sulfasalazine and valproic acid promotes human glioblastoma cell death through imbalance of the intracellular oxidative response
CG Garcia, SA Kahn, LHM Geraldo, I Romano… - Molecular …, 2018 - Springer
Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor and
still lacks effective therapeutic strategies. It has already been shown that old drugs like …
still lacks effective therapeutic strategies. It has already been shown that old drugs like …
Combined inhibition of HDAC and EGFR reduces viability and proliferation and enhances STAT3 mRNA expression in glioblastoma cells
M Buendia Duque, KV Pinheiro, A Thomaz… - Journal of Molecular …, 2019 - Springer
Abstract Changes in expression of histone deacetylases (HDACs), which epigenetically
regulate chromatin structure, and mutations and amplifications of the EGFR gene, which …
regulate chromatin structure, and mutations and amplifications of the EGFR gene, which …