A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Pig islets are an alternative source for islet transplantation to treat type 1 diabetes (T1D), but
reproducible curative potential in the pig-to-nonhuman primate (NHP) model has not been …

Whole-organ pancreas and islet transplantations are performed in a highly selected group of
patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by …

Background. This study assessed the capacity of alginate-encapsulated islets to reverse
diabetes in a pig-to-primate model. Methods. Adult pig islets were encapsulated in …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

摘要β 细胞补充治疗, 包括同种异体胰腺与胰岛移植, 对于脆性1 型糖尿病患者来说可使其
HbA1c 水平正常化, 但是供体短缺是个严重的问题. 为了克服这个问题, 异种移植是一种吸引人 …

Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …

The widespread clinical implementation of alloislet transplantation as therapy for type 1
diabetes has been hindered by the lack of suitable islet donors. Pig-to-human islet …