Progress in xenotransplantation: overcoming immune barriers
M Sykes, DH Sachs - Nature Reviews Nephrology, 2022 - nature.com
A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Transplanting organs from pigs to humans
M Sykes, DH Sachs - Science immunology, 2019 - science.org
The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …
Current status of xenotransplantation research and the strategies for preventing xenograft rejection
Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
[HTML][HTML] Long-term control of diabetes in immunosuppressed nonhuman primates (NHP) by the transplantation of adult porcine islets
Pig islets are an alternative source for islet transplantation to treat type 1 diabetes (T1D), but
reproducible curative potential in the pig-to-nonhuman primate (NHP) model has not been …
reproducible curative potential in the pig-to-nonhuman primate (NHP) model has not been …
Transplant strategies for type 1 diabetes: whole pancreas, islet and porcine beta cell therapies
MD Bellin, TB Dunn - Diabetologia, 2020 - Springer
Whole-organ pancreas and islet transplantations are performed in a highly selected group of
patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by …
patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by …
Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression
D Dufrane, RM Goebbels, P Gianello - Transplantation, 2010 - journals.lww.com
Background. This study assessed the capacity of alginate-encapsulated islets to reverse
diabetes in a pig-to-primate model. Methods. Adult pig islets were encapsulated in …
diabetes in a pig-to-primate model. Methods. Adult pig islets were encapsulated in …
The pathobiology of pig‐to‐primate xenotransplantation: a historical review
DKC Cooper, MB Ezzelarab, H Hara… - …, 2016 - Wiley Online Library
The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …
Current status and future of clinical islet xenotransplantation: 临床异种胰岛移植的现状与将来
S Matsumoto, M Tomiya, O Sawamoto - Journal of Diabetes, 2016 - Wiley Online Library
摘要β 细胞补充治疗, 包括同种异体胰腺与胰岛移植, 对于脆性1 型糖尿病患者来说可使其
HbA1c 水平正常化, 但是供体短缺是个严重的问题. 为了克服这个问题, 异种移植是一种吸引人 …
HbA1c 水平正常化, 但是供体短缺是个严重的问题. 为了克服这个问题, 异种移植是一种吸引人 …
Progress in pig‐to‐non‐human primate transplantation models (1998–2013): a comprehensive review of the literature
DKC Cooper, V Satyananda, B Ekser… - …, 2014 - Wiley Online Library
Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …
[HTML][HTML] CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates
P Thompson, K Cardona, M Russell, IR Badell… - American Journal of …, 2011 - Elsevier
The widespread clinical implementation of alloislet transplantation as therapy for type 1
diabetes has been hindered by the lack of suitable islet donors. Pig-to-human islet …
diabetes has been hindered by the lack of suitable islet donors. Pig-to-human islet …