Polyglutamine disorders: Pathogenesis and potential drug interventions
S Tandon, P Aggarwal, S Sarkar - Life Sciences, 2024 - Elsevier
Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …
Modeling neurodegenerative and neurodevelopmental disorders in the Drosophila mushroom body
A Stahl, SM Tomchik - Learning & Memory, 2024 - learnmem.cshlp.org
The common fruit fly Drosophila melanogaster provides a powerful platform to investigate
the genetic, molecular, cellular, and neural circuit mechanisms of behavior. Research in this …
the genetic, molecular, cellular, and neural circuit mechanisms of behavior. Research in this …
Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models
S Tandon, S Sarkar - Nutritional Neuroscience, 2024 - Taylor & Francis
ABSTRACT Human polyglutamine [poly (Q)] disorders such as Huntington's disease,
different types of ataxias, etc. are devastating brain illnesses which are characterised by the …
different types of ataxias, etc. are devastating brain illnesses which are characterised by the …
Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders
AE Ortega-Regules, JA Martínez-Thomas… - Plants, 2024 - mdpi.com
Carotenoids constitute compounds of significant biological interest due to their multiple
biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and …
biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and …
Myc functions downstream of InR and their concurrent upregulation additively restricts pathogenesis of human poly (Q) disorders in Drosophila disease models
S Tandon, S Sarkar - The International Journal of Biochemistry & Cell …, 2024 - Elsevier
Abstract Human polyglutamine [poly (Q)] disorders are caused by abnormal expansion of
CAG repeats in one gene (disease specific), yet a plethora of cellular pathways are found to …
CAG repeats in one gene (disease specific), yet a plethora of cellular pathways are found to …
[HTML][HTML] Simultaneous HPLC of Metformin, Glipizide and Gliclazide, and Metformin Uptake and Protection of HEI-OC1 from Hyperglycaemia
A Gedawy, H Al-Salami, CR Dass - Applied Sciences, 2024 - mdpi.com
The antidiabetic drugs metformin, glipizide and gliclazide have been used for many years to
control blood glucose levels. In recent years, they have gained importance in non-diabetic …
control blood glucose levels. In recent years, they have gained importance in non-diabetic …
Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status
Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2
diabetes. This study compiles exhaustively all accessible information on glipizide, from …
diabetes. This study compiles exhaustively all accessible information on glipizide, from …
Prospects of antidiabetic drugs in the treatment of neurodegenerative disease
Neurodegenerative diseases (NDs) stand for a group of disorders characterized by the
progressive loss of neurons in the brain and peripheral organs, resulting in motor and …
progressive loss of neurons in the brain and peripheral organs, resulting in motor and …