Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

Age-related macular degeneration (AMD) is a progressive neurodegeneration disease that
causes photoreceptor demise and vision impairments. In AMD pathogenesis, the primary …

Purpose To establish the safety, tolerability, pharmacokinetics, and pharmacodynamics of
an intravitreal injection of recombinant human complement factor H (CFH), GEM103, in …

Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or
excessive activity of the complement system. Consequently, cells not directly affected by an …

The complement is a component of the innate immune system designed to fight infections
and tissue-or age-related damages. Complement activation creates an inflammatory …

Complement factor H (CFH), a major soluble inhibitor of complement, is a plasma protein
that directly interacts with the endothelium of blood vessels. Mutations in the CFH gene lead …

Angiogenesis, the process of formation of new capillaries from existing blood vessels, is
required for multiple physiological and pathological processes. Complement factor H (CFH) …

Sepsis is a heterogeneous syndrome caused by the immune response to severe infection.
This study aimed to investigate the value of cardiac troponin I, lactic acid, procalcitonin, and …

Age-related macular degeneration (AMD) continues to be a leading cause of severe vision
impairment affecting millions worldwide. The late stages of AMD are characterized by outer …

The complement system is a component of the innate immune response in that recognizes
and eliminates pathogens and damaged cells. In addition to its role in the systemic immune …