Synucleins: new data on misfolding, aggregation and role in diseases
A Surguchov, A Surguchev - Biomedicines, 2022 - mdpi.com
The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …
The synucleins and the astrocyte
AJ Myers, A Brahimi, IJ Jenkins, AO Koob - Biology, 2023 - mdpi.com
Simple Summary Emerging evidence on synucleins and astrocytes warrants closer
inspection of their functional relationship. The expression and release of synucleins from the …
inspection of their functional relationship. The expression and release of synucleins from the …
Excess phosphoserine-129 α-synuclein induces synaptic vesicle trafficking and declustering defects at a vertebrate synapse
JN Wallace, ZC Crockford… - Molecular biology of …, 2024 - Am Soc Cell Biol
α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In
Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …
Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …
Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis
Various forms of Parkinson's disease, including its common sporadic form, are characterized
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …
Synucleinopathies: Intrinsic and Extrinsic Factors
AK Lomeli-Lepe, JL Castañeda-Cabral… - Cell Biochemistry and …, 2023 - Springer
Abstract α-Synucleinopathies are a group of neurodegenerative disorders characterized by
alterations in α-synuclein (α-syn), a protein associated with membrane phospholipids …
alterations in α-synuclein (α-syn), a protein associated with membrane phospholipids …
[HTML][HTML] A Highlights from MBoC Selection: Excess phosphoserine-129 α-synuclein induces synaptic vesicle trafficking and declustering defects at a vertebrate …
JN Wallace, ZC Crockford… - Molecular Biology of …, 2024 - ncbi.nlm.nih.gov
Abstract α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking.
In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …
In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …
Cancer in pathologically confirmed multiple system atrophy
Purpose The aim of this study was to assess whether cancer occurs with increased
frequency in multiple system atrophy (MSA). The pathological hallmark of MSA is glial …
frequency in multiple system atrophy (MSA). The pathological hallmark of MSA is glial …
[HTML][HTML] Нокаут генов α-, β-, и γ-синуклеинов у мышей приводит к изменению содержания ряда липидов в печени и плазме крови
ЕА Лысикова, КД Чапров - Научные результаты биомедицинских …, 2022 - cyberleninka.ru
Актуальность: В настоящее время активно исследуется функция белков семейства
синуклеинов в реакциях синтеза липидов и жирных кислот в дополнение к уже …
синуклеинов в реакциях синтеза липидов и жирных кислот в дополнение к уже …
Absolute quantification of synuclein proteoforms in plasma in patients with Synucleinopathies by LC-MRM mass spectrometry
P Marie-Laure, V Margaux, V Jérôme, M Etienne… - medRxiv, 2023 - medrxiv.org
Abstract Background Synucleinopathies include Parkinson's disease (PD), Lewy body
dementia (LBD) and Multiple system atrophy (MSA). Most studies of synucleinopathies rely …
dementia (LBD) and Multiple system atrophy (MSA). Most studies of synucleinopathies rely …
Computational modelling of the ph effect on intrinsically disordered proteins
C Privat Contreras - 2023 - diposit.ub.edu
[eng] Intrinsically disordered proteins (IDPs) landed on the molecular biology framework at
the turn of the 20th century to challenge the established protein function-structure paradigm …
the turn of the 20th century to challenge the established protein function-structure paradigm …