Synucleins: new data on misfolding, aggregation and role in diseases

A Surguchov, A Surguchev - Biomedicines, 2022 - mdpi.com
The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …

The synucleins and the astrocyte

AJ Myers, A Brahimi, IJ Jenkins, AO Koob - Biology, 2023 - mdpi.com
Simple Summary Emerging evidence on synucleins and astrocytes warrants closer
inspection of their functional relationship. The expression and release of synucleins from the …

Excess phosphoserine-129 α-synuclein induces synaptic vesicle trafficking and declustering defects at a vertebrate synapse

JN Wallace, ZC Crockford… - Molecular biology of …, 2024 - Am Soc Cell Biol
α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In
Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …

Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis

J Burré, RH Edwards, G Halliday, AE Lang… - Movement …, 2024 - Wiley Online Library
Various forms of Parkinson's disease, including its common sporadic form, are characterized
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …

Synucleinopathies: Intrinsic and Extrinsic Factors

AK Lomeli-Lepe, JL Castañeda-Cabral… - Cell Biochemistry and …, 2023 - Springer
Abstract α-Synucleinopathies are a group of neurodegenerative disorders characterized by
alterations in α-synuclein (α-syn), a protein associated with membrane phospholipids …

[HTML][HTML] A Highlights from MBoC Selection: Excess phosphoserine-129 α-synuclein induces synaptic vesicle trafficking and declustering defects at a vertebrate …

JN Wallace, ZC Crockford… - Molecular Biology of …, 2024 - ncbi.nlm.nih.gov
Abstract α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking.
In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …

Cancer in pathologically confirmed multiple system atrophy

WP Cheshire, S Koga, PW Tipton, H Sekiya… - Clinical Autonomic …, 2023 - Springer
Purpose The aim of this study was to assess whether cancer occurs with increased
frequency in multiple system atrophy (MSA). The pathological hallmark of MSA is glial …

[HTML][HTML] Нокаут генов α-, β-, и γ-синуклеинов у мышей приводит к изменению содержания ряда липидов в печени и плазме крови

ЕА Лысикова, КД Чапров - Научные результаты биомедицинских …, 2022 - cyberleninka.ru
Актуальность: В настоящее время активно исследуется функция белков семейства
синуклеинов в реакциях синтеза липидов и жирных кислот в дополнение к уже …

Absolute quantification of synuclein proteoforms in plasma in patients with Synucleinopathies by LC-MRM mass spectrometry

P Marie-Laure, V Margaux, V Jérôme, M Etienne… - medRxiv, 2023 - medrxiv.org
Abstract Background Synucleinopathies include Parkinson's disease (PD), Lewy body
dementia (LBD) and Multiple system atrophy (MSA). Most studies of synucleinopathies rely …

Computational modelling of the ph effect on intrinsically disordered proteins

C Privat Contreras - 2023 - diposit.ub.edu
[eng] Intrinsically disordered proteins (IDPs) landed on the molecular biology framework at
the turn of the 20th century to challenge the established protein function-structure paradigm …