With a bang, a new family of potassium channels has exploded into view. Although KCNK
channels were discovered only five years ago, they already outnumber other channel types …

The γ-aminobutyric acidB (GABAB) receptor was first demonstrated on presynaptic terminals
where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter …

The two-pore-domain K+ channels, or K2P channels, constitute a novel class of K+ channel
subunits. They have four transmembrane segments and are active as dimers. The tissue …

Abstract TWIK‐1, TREK‐1 and TASK K+ channels comprise a class of pore‐forming subunits
with four membrane‐spanning segments and two P domains. Here we report the cloning of …

Serotonergic neurons in the medulla have recently been shown to be sensors of carbon
dioxide and pH. There is compelling evidence that the co-release of serotonin, substance P …

The respiratory rhythm is generated by the interaction of oscillators disparately distributed
throughout the pons, medulla, and spinal cord. According to the classic model, the …

Excessive alcohol intake, eg, binge drinking, is a serious and mounting public health
problem in the United States and throughout the world. Hence the need for novel insights …

TRAAK is the sole member of the emerging class of 2P domain K+ channels to be
exclusively expressed in neuronal cells. TRAAK produces baseline K+ currents which are …

Background K+ channels exert control over neuronal excitability by regulating resting
potential and input resistance. Here, we show that GABAB receptor‐mediated activation of a …

A key feature of potassium channel function is the ability to switch between conducting and
non-conducting states by undergoing conformational changes in response to cellular or …