Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …

Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …

Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits
called plaques and tangles are neuropathological hallmarks of Alzheimer's disease (AD) …

Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks
of Alzheimer's disease (AD), which is characterized by the conversion of monomeric …

Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary
tangles is a hallmark of Alzheimer's disease (AD). Tau pathology correlates not only with …

Parkinson's disease (PD) is primarily characterized by loss of dopaminergic neurons in the
substantia nigra pars compacta region of the brain and accumulation of aggregated forms of …

Self-assembly of proteins into amyloid fibrils is a hallmark of various diseases, including
Alzheimer's disease (AD) and Type-2 diabetes Mellitus (T2DM). Aggregation of specific …

Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …

Introduction Protein aggregation and deposition of uniformly arranged amyloid fibrils in the
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of
extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) …