Since their discovery as distinct receptor proteins, the specific physiopathological role of
sigma receptors (σRs) has been deeply investigated. It has been reported that these …

In this study, a panel of 46 compounds containing five different scaffolds known to have high
σ2 receptor affinity were screened. 6, 7-Dimethoxy-2-[4-(4-methoxyphenyl) butan-2-yl]-1, 2 …

Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain,
but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The …

Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to
higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the …

Cancer is a multifactorial disease that may be tackled by targeting different signaling
pathways. Heme oxygenase-1 (HO-1) and sigma receptors (σRs) are both overexpressed in …

Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic
strategy to counteract neurodegeneration, cancer progression, and viral infections, including …

In our continuing effort to develop novel sigma receptor (SR) ligands, we present the design,
synthesis and binding studies of a small library of aminopropylcarboxamide derivatives …

Abstract Sigma-2 receptor/transmembrane protein 97 (TMEM97) is upregulated in cancer
cells compared to normal cells. Traditional sigma-2 receptor agonists induce apoptosis and …

Among the eye tumors, uveal melanoma is one of the most diffuse and aggressive, affecting
mainly the choroid, but also the ciliary body and the iris. Promising pharmaceutical therapies …