[HTML][HTML] Origin, development, and synaptogenesis of cortical interneurons

A Llorca, R Deogracias - Frontiers in Neuroscience, 2022 - frontiersin.org
The mammalian cerebral cortex represents one of the most recent and astonishing
inventions of nature, responsible of a large diversity of functions that range from sensory …

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

E Favuzzi, R Deogracias, A Marques-Smith, P Maeso… - Science, 2019 - science.org
How neuronal connections are established and organized into functional networks
determines brain function. In the mammalian cerebral cortex, different classes of GABAergic …

[HTML][HTML] Physiological and pathological roles of mammalian NEK7

Z Sun, W Gong, Y Zhang, Z Jia - Frontiers in physiology, 2020 - frontiersin.org
NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and
physiological roles of NEK7 have been widely reported in many studies. To date, the major …

[HTML][HTML] Vision-dependent specification of cell types and function in the developing cortex

S Cheng, S Butrus, L Tan, R Xu, S Sagireddy… - Cell, 2022 - cell.com
The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is
poorly understood at the level of cell types. We explore this in the mouse primary visual …

[HTML][HTML] Activity-dependent plasticity of axo-axonic synapses at the axon initial segment

A Pan-Vazquez, W Wefelmeyer, VG Sabater, G Neves… - Neuron, 2020 - cell.com
The activity-dependent rules that govern the wiring of GABAergic interneurons are not well
understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control …

[HTML][HTML] NEK7 regulates NLRP3 inflammasome activation and neuroinflammation post-traumatic brain injury

Y Chen, J Meng, F Bi, H Li, C Chang, C Ji… - Frontiers in molecular …, 2019 - frontiersin.org
As one of the most common causes of mortality and disability, traumatic brain injury (TBI) is a
huge psychological and economic burden to patients, families, and societies worldwide …

CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity

W Guo, H Wang, A Kumar Tharkeshwar… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction The most common genetic cause of frontotemporal dementia (FTD) and
amyotrophic lateral sclerosis (ALS) are hexanucleotide repeats in chromosome 9 open …

[HTML][HTML] Assessing transcriptome quality in patch-seq datasets

SJ Tripathy, L Toker, C Bomkamp… - Frontiers in Molecular …, 2018 - frontiersin.org
Patch-seq, combining patch-clamp electrophysiology with single-cell RNA-sequencing
(scRNAseq), enables unprecedented access to a neuron's transcriptomic …

[HTML][HTML] UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting

CJ Drozd, CC Quinn - Development, 2023 - journals.biologists.com
ABSTRACT KIF5C is a kinesin-1 heavy chain that has been associated with
neurodevelopmental disorders. Although the roles of kinesin-1 in axon transport are well …

[HTML][HTML] NEK7 coordinates rapid neuroinflammation after subarachnoid hemorrhage in mice

G Li, Y Dong, D Liu, Z Zou, G Hao, X Gao, P Pan… - Frontiers in …, 2020 - frontiersin.org
Background: Subarachnoid hemorrhage (SAH) is a devastating disease which leads to high
morbidity and mortality. Recent studies have indicated that, never in mitosis gene A-related …