Roles, functions, and mechanisms of long non-coding RNAs in cancer

Y Fang, MJ Fullwood - Genomics, Proteomics and …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in
chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through …

Paracrine mechanisms of mesenchymal stromal cells in angiogenesis

S Maacha, H Sidahmed, S Jacob… - Stem cells …, 2020 - Wiley Online Library
The role of the mesenchymal stromal cell‐(MSC‐) derived secretome is becoming
increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous …

Circulating noncoding RNAs as biomarkers of cardiovascular disease and injury

J Viereck, T Thum - Circulation research, 2017 - Am Heart Assoc
The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on
mammalian genomes and transcriptomes, as well as their organization and regulation …

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

R Micheletti, I Plaisance, BJ Abraham, A Sarre… - Science translational …, 2017 - science.org
Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac
development and disease. However, our understanding of the importance of these …

[HTML][HTML] CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis

S Ounzain, R Micheletti, C Arnan, I Plaisance… - Journal of molecular and …, 2015 - Elsevier
Long noncoding RNAs (lncRNAs) are emerging as important regulators of developmental
pathways. However, their roles in human cardiac precursor cell (CPC) remain unexplored …

Non-coding RNA therapeutics for cardiac regeneration

L Braga, H Ali, I Secco, M Giacca - Cardiovascular research, 2021 - academic.oup.com
A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …

Non-coding RNAs in mesenchymal stem cell-derived extracellular vesicles: deciphering regulatory roles in stem cell potency, inflammatory resolve, and tissue …

F Fatima, K Ekstrom, I Nazarenko, M Maugeri… - Frontiers in …, 2017 - frontiersin.org
Extracellular vesicles (EVs) are heterogeneous populations of nano-and micro-sized
vesicles secreted by various cell types. There is mounting evidence that EVs have …

Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice

M Ballarino, A Cipriano, R Tita, T Santini… - The EMBO …, 2018 - embopress.org
Myogenesis is a highly regulated process that involves the conversion of progenitor cells
into multinucleated myofibers. Besides proteins and mi RNA s, long noncoding RNA s (lnc …

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

P Aghagolzadeh, I Plaisance, R Bernasconi… - Circulation, 2023 - Am Heart Assoc
BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts
differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation …

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

C Bär, S Chatterjee, I Falcão Pires… - Cardiovascular …, 2020 - academic.oup.com
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-
coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs …