Circadian rhythm as a therapeutic target

W Ruan, X Yuan, HK Eltzschig - Nature Reviews Drug Discovery, 2021 - nature.com
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Time-restricted eating for the prevention and management of metabolic diseases

ENC Manoogian, LS Chow, PR Taub… - Endocrine …, 2022 - academic.oup.com
Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE,
humans) are an emerging behavioral intervention approach based on the understanding of …

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

V Acosta-Rodríguez, F Rijo-Ferreira, M Izumo, P Xu… - Science, 2022 - science.org
Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Magnetic field effects in biology from the perspective of the radical pair mechanism

H Zadeh-Haghighi, C Simon - Journal of the Royal …, 2022 - royalsocietypublishing.org
Hundreds of studies have found that weak magnetic fields can significantly influence various
biological systems. However, the underlying mechanisms behind these phenomena remain …

[HTML][HTML] Genomics of circadian rhythms in health and disease

F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

[PDF][PDF] Sleep in normal aging

J Li, MV Vitiello, NS Gooneratne - Sleep medicine clinics, 2022 - Elsevier
Sleep is a key determinant of healthy and cognitive aging. Sleep patterns change with
aging, independent of other factors, and include advanced sleep timing, shortened nocturnal …

Circadian rhythms and the molecular clock in cardiovascular biology and disease

S Crnko, BC Du Pré, JPG Sluijter… - Nature Reviews …, 2019 - nature.com
The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

[HTML][HTML] Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Assessment of the cortisol awakening response: Expert consensus guidelines

T Stalder, C Kirschbaum, BM Kudielka, EK Adam… - …, 2016 - Elsevier
The cortisol awakening response (CAR), the marked increase in cortisol secretion over the
first 30–45 min after morning awakening, has been related to a wide range of psychosocial …

[HTML][HTML] The aging clock: circadian rhythms and later life

S Hood, S Amir - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …