The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - Signal transduction and …, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Potential adverse effects of resveratrol: A literature review

A Shaito, AM Posadino, N Younes, H Hasan… - International journal of …, 2020 - mdpi.com
Due to its health benefits, resveratrol (RE) is one of the most researched natural
polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the …

The therapeutic potential of resveratrol: a review of clinical trials

AY Berman, RA Motechin, MY Wiesenfeld… - NPJ precision …, 2017 - nature.com
Resveratrol is a nutraceutical with several therapeutic effects. It has been shown to mimic
effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the …

Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products

J Jakab, B Miškić, Š Mikšić, B Juranić… - … syndrome and obesity, 2021 - Taylor & Francis
Obesity is recognized as a severe threat to overall human health and is associated with type
2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal …

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases

AE Kane, DA Sinclair - Circulation research, 2018 - Am Heart Assoc
The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Anti-obesity effects of polyphenol intake: Current status and future possibilities

M Boccellino, S D'Angelo - International journal of molecular sciences, 2020 - mdpi.com
The prevalence of obesity has steadily increased worldwide over the past three decades.
The conventional approaches to prevent or treat this syndrome and its associated …

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

MS Bonkowski, DA Sinclair - Nature reviews Molecular cell biology, 2016 - nature.com
Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

Biological activities of stilbenoids

BC Akinwumi, KAM Bordun, HD Anderson - International journal of …, 2018 - mdpi.com
Stilbenoids are a group of naturally occurring phenolic compounds found in various plant
species. They share a common backbone structure known as stilbene, but differ in the …

Antioxidant effects of resveratrol in the cardiovascular system

N Xia, A Daiber, U Förstermann… - British journal of …, 2017 - Wiley Online Library
The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …