With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …

The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …

Preclinical evidence demonstrates that senescent cells accumulate with aging and that
senolytics delay multiple age-related morbidities, including bone loss. Thus, we conducted a …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

Cellular senescence has gained increasing interest during recent years, particularly due to
causal involvement in the aging process corroborated by multiple experimental findings …

We propose the beneficial effects of exercise are in part mediated through the prevention
and elimination of senescent cells. Exercise counters multiple forms of age-related …

An accumulating body of evidence supports the hypothesis that cancer and/or cancer
treatment is associated with accelerated aging. The majority of these data come from the …

In an ageing population of patients with heart disease, preinterventional frailty assessment
for risk prediction is gaining relevance both in cardiac surgery and transcatheter valve …

Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Cellular senescence, a state of irreversible growth arrest triggered by various stressors,
engages in a category of pathological processes, whereby senescent cells accumulate in …