The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …

Background Cerebral ischemia–reperfusion (I/R) injury is a major cause of early
complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in …

As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its
control over leukocyte-mediated immune responses. However, it is now recognized that …

Chronic diseases that affect our society are made more complex by comorbidities and are
poorly managed by the current pharmacology. While all present inflammatory …

The human formyl-peptide receptor (FPR)-2 is a G protein-coupled receptor that transduces
signals from lipoxin A 4, annexin A1, and serum amyloid A (SAA) to regulate inflammation. In …

Polymorphonuclear leukocyte (PMN)–derived microparticles display inhibitory properties on
target cells as assessed in vitro; since PMNs contain abundant amounts of the endogenous …

Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …

Inflammation is the body's way of defending itself against noxious stimuli and pathogens.
Under normal circumstances, the body is able to eliminate the insult and subsequently …