Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

Pain associates both sensory and emotional aversive components, and often leads to
anxiety and depression when it becomes chronic. Here, we characterized, in a mouse …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Importance High placebo responses have been observed across a wide range of
pathologies, severely impacting drug development. Objective To examine neurochemical …

Curcumin, a phenolic compound present in Curcuma longa, has been reported to exert
antinociceptive effects in some animal models, but the mechanisms remain to be elucidated …

Since the serendipitous discovery of the first class of modern antidepressants in the 1950's,
all pharmacotherapies approved by the Food and Drug Administration for major depressive …

Neuropathic pain arises as a consequence of a lesion or a disease affecting the
somatosensory system. This syndrome results from maladaptive changes in injured sensory …

Objective: Tricyclic antidepressants (TCAs) are one of the first-line pharmacological
treatments against neuropathic pain. TCAs increase the extracellular concentrations of …

Selective block of Na V 1.7 promises to produce non-narcotic analgesic activity without
motor or cognitive impairment. Several Na V 1.7-selective blockers have been reported, but …